Yi Feng^1,#, Haoxin Yang², Guicai Liang¹, Jun Chen³, Tao Li¹, Yingjuan Wang⁴, Jilin Chang¹, Yan Li³, Meng Yang¹, Xilong Zhou¹, Zhiqiang Wang^5,*, Chunlei Ge^1,*

Oncology Research, Vol.33, No.12, pp. 3801-3836, 2025, DOI:10.32604/or.2025.067824 - 27 November 2025

Abstract Immune checkpoint inhibitor (ICI) has limited efficacy in the treatment of immune “cold” tumors. Due to insufficient T cell infiltration and heterogeneous programmed death ligand 1 (PD-L1) expression, the ORR is only 5%–8% compared with 30%–40% of “hot” tumors. This article reviews the synergistic mechanism, clinical efficacy and optimization strategy of oncolytic virus (OVs) combined with ICIs in the treatment of refractory malignant tumors. Systematic analysis of mechanistic interactions across tumor types and clinical trial data demonstrates that OVs transform the immunosuppressive microenvironment by inducing immunogenic cell death and activating innate immunity. Concurrently, ICIs enhance… More >

Junyu Deng^1,2, Rui Zhang^1,*, Xudong Zhao³, Hongzhi Xu^1,2, Peng Ji¹, Zizhen Zhang¹, Yifan Yang¹

Energy Engineering, Vol.122, No.10, pp. 4153-4168, 2025, DOI:10.32604/ee.2025.065906 - 30 September 2025

Abstract Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction. Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments. However, the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood. In this study, a multiphase, multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments, incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea. The effects… More >

Lachezar Filchev^1,*, Milen Chanev¹, Galin Petrov²

Revue Internationale de Géomatique, Vol.34, pp. 513-533, 2025, DOI:10.32604/rig.2025.064280 - 06 August 2025

Abstract This review article provides a comprehensive analysis of Earth Observation (EO) applications for soil health assessment in Europe and abroad. The study explores the effectiveness of EO in capturing contextual information about various soil properties and conditions, as well as its role in monitoring soil health over time. The authors examine the current state of operational, semi-operational, and developing EO products and services relevant to soil health indicators. These include vegetation cover, forest cover, soil organic carbon, soil structure, landscape heterogeneity, and the presence of soil pollutants, excess nutrients, and salts. The review identifies gaps… More > Graphic Abstract

Yajie Bai^1,*, Jian Hou^2,3, Yongge Liu^2,3

Energy Engineering, Vol.122, No.6, pp. 2503-2518, 2025, DOI:10.32604/ee.2025.063198 - 29 May 2025

Abstract Natural gas hydrate widely exists in the South China Sea as clean energy. A three-phase transition layer widely exists in low permeability Class I hydrates in the Shenhu offshore area. Therefore, taking into account the low-permeability characteristics with an average permeability of 5.5 mD and moderate heterogeneity, a 3-D geological model of heterogeneous Class I hydrate reservoirs with three-phase transition layers is established by Kriging interpolation and stochastic modeling method, and a numerical simulation model is used to describe the depressurization production performance of the reservoir. With the development of depressurization, a specific range of… More >

Dexian Li¹, Wencan Li², Xin Lin^3,*, Xingchen Zhu^4,*

International Journal of Mental Health Promotion, Vol.27, No.1, pp. 1-17, 2025, DOI:10.32604/ijmhp.2024.058744 - 31 January 2025

Abstract Background: The phenomenon of academic anxiety has been demonstrated to exert a considerable influence on students’ academic engagement, leading to the emergence of a phenomenon known as “learned helplessness” and undermining the self-confidence and motivation of high school students. Using acceptance-rejection theory, this study elucidated how a rejective parenting style affects Chinese high school students’ academic anxiety and explored the urban-rural heterogeneity of this relationship. Methods: Data were analyzed using a stratified whole-cluster random sampling method. There are a total of 30,000 high school students in the three regions of northern and central China (from… More >

HAO WU^#, NA HUO^#, SITUO WANG, ZIWEI LIU, YI JIANG^*, QUAN SHI^*

BIOCELL, Vol.48, No.11, pp. 1531-1542, 2024, DOI:10.32604/biocell.2024.054278 - 07 November 2024

Abstract Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment. Therefore, a full understanding of stem cells and their related regulatory mechanisms in disease treatment is conducive to improving the therapeutic effect of stem cells. However, thus far, there are still many unsolved mysteries in the field of stem cells due to technical limitations, which hinder the in-depth exploration of stem cells and their wide clinical application. Single-cell sequencing (SCS) has provided very powerful and unbiased insights into cell gene expression profiles at the single-cell level, bringing exciting results to More >

Ke Li^1,*, Xiaofeng Wang^1,2,*, Hu Wang¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1391-1407, 2024, DOI:10.32604/cmc.2024.054484 - 15 October 2024

Abstract In the realm of data privacy protection, federated learning aims to collaboratively train a global model. However, heterogeneous data between clients presents challenges, often resulting in slow convergence and inadequate accuracy of the global model. Utilizing shared feature representations alongside customized classifiers for individual clients emerges as a promising personalized solution. Nonetheless, previous research has frequently neglected the integration of global knowledge into local representation learning and the synergy between global and local classifiers, thereby limiting model performance. To tackle these issues, this study proposes a hierarchical optimization method for federated learning with feature alignment… More >

KERAN JIA¹, YANHAO ZHANG¹, MENGYU JIANG², MENGGE CUI², JIA WANG², JIAJIA ZHANG², HUIHAI ZHAO², MENGYAN LI², HUA WANG², QUANMING ZOU^1,#,*, HAO ZENG^1,#,*

BIOCELL, Vol.48, No.9, pp. 1355-1368, 2024, DOI:10.32604/biocell.2024.051383 - 04 September 2024

Abstract Objective: Candida albicans is a common fungal pathogen that triggers complex host defense mechanisms, including coordinated innate and adaptive immune responses, to neutralize invading fungi effectively. Exploring the immune microenvironment has the potential to inform the development of therapeutic strategies for fungal infections. Methods: The study analyzed individual immune cell profiles in peripheral blood mononuclear cells from Candida albicans-infected mice and healthy control mice using single-cell transcriptomics, fluorescence quantitative PCR, and Western blotting. We investigated intergroup differences in the dynamics of immune cell subpopulation infiltration, pathway enrichment, and differentiation during Candida albicans infection. Results: Our findings indicate that infiltration… More >

Jiehao Ye, Wen Cheng, Xiaolong Liu, Wenyi Zhu, Xuan’ang Wu, Shigen Shen^*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2743-2769, 2024, DOI:10.32604/cmc.2024.049985 - 15 May 2024

Abstract The Internet of Things (IoT) has characteristics such as node mobility, node heterogeneity, link heterogeneity, and topology heterogeneity. In the face of the IoT characteristics and the explosive growth of IoT nodes, which brings about large-scale data processing requirements, edge computing architecture has become an emerging network architecture to support IoT applications due to its ability to provide powerful computing capabilities and good service functions. However, the defense mechanism of Edge Computing-enabled IoT Nodes (ECIoTNs) is still weak due to their limited resources, so that they are susceptible to malicious software spread, which can compromise… More >

Di Qiu^1,3,4, Rongpei Shi^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1017-1028, 2024, DOI:10.32604/cmes.2024.048797 - 16 April 2024

Abstract For media with inclusions (e.g., precipitates, voids, reinforcements, and others), the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the interfaces. These stress fields depend on the inclusions’ size, shape, and distribution and will respond instantly to the evolving microstructure. This study develops a phase-field model concerning modulus heterogeneity. The effect of modulus heterogeneity on the growth process and equilibrium state of the α plate in Ti-6Al-4V during precipitation is evaluated. The α precipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the… More >