Rui Wu¹, Yehong Li², Hongjie Guo^3,*, Gangqiang Hu³, Changjun Zhou^3,*, Qile Zou⁴

CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.083715 - 13 August 2026

Abstract Federated learning (FL) enables collaborative training of deep neural architectures while preserving data privacy, yet its performance often deteriorates in non-IID scenarios, which stems from client-side distribution drift and divergent local updates induced by pervasive data heterogeneity. This challenge is particularly critical for maintaining the structural consistency and generalization of neural models across diverse, distributed sources with significant distribution shifts. In this paper, we investigate how to effectively mitigate label distribution shift and feature distribution skew to enhance the global representation stability of neural architectures. We propose Federated Learning with Consistency Optimization Algorithms (FedCO), a… More >

Jian-Lei Kang^1,2, Yu-Jie Xu³, Qi-Tai Zhao⁴, Bing Zhang⁵, Xin Xu^2,*, Bo Yang^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.079221 - 16 June 2026

Abstract Background: Glioma is among the most malignant brain tumors, and its heterogeneity contributes significantly to treatment failure. Comprehensive profiling of cellular and molecular heterogeneity across different glioma stages and recurrence states is crucial for understanding therapeutic resistance and identifying novel targets. Accordingly, this study sought to systematically characterize the cellular and molecular heterogeneity of glioma across different stages and recurrence states using single-cell RNA sequencing, and to identify prognostic subtypes and potential therapeutic targets. Methods: We integrated public single-cell RNA sequencing data from glioma specimens, including lower-grade glioma (LGG), glioblastoma (GBM), and paired primary and recurrent… More >

Xiankai Ji^1,2, Manchun Li^1,2,*, Nan Xia^1,2,3

Revue Internationale de Géomatique, Vol.35, pp. 315-332, 2026, DOI:10.32604/rig.2026.084921 - 11 June 2026

Abstract Against the backdrop of rapid global urbanization, revealing the indirect ecological effects triggered by urban environmental restructuring and human management interventions carries early-warning significance for preventing cliff-like vegetation degradation driven by unchecked urban expansion. Existing studies predominantly rely on linear assumptions and neglect the temporal lags inherent in ecological responses, making it difficult to capture the long-run and short-run dynamics as well as potential nonlinear thresholds of indirect impacts. Using Nanjing as the study region, this research constructs a spatiotemporal panel dataset at 1 km × 1 km resolution based on multi-source remote sensing data… More >

Cristina Díaz del Arco^1,2,*, Luis Ortega Medina^1,2, Patricia Barreiro Sanabria², Andrés Sánchez Pernaute³, Lourdes Estrada Muñoz⁴, Elena Molina Roldán⁵, María Jesús Fernández Aceñero^1,2

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.075609 - 21 May 2026

Abstract Background: Claudin 18.2 (CLDN18.2) has become a clinically relevant therapeutic target in gastric adenocarcinoma (GC), with zolbetuximab now approved for use in CLDN18.2-positive, HER2-negative advanced disease. The aim of this study was to evaluate the prevalence, intratumoral reproducibility, and clinicopathologic associations of CLDN18.2 expression in a Western cohort of resected GC. Methods: CLDN18.2 expression was evaluated by immunohistochemistry in 204 resected GCs arranged in tissue microarrays containing duplicate tumor cores corresponding to the tumor center and invasive front. Correlations between paired cores, clinicopathologic parameters, additional biomarkers (E-cadherin, HER2, p53, mismatch repair (MMR)), and clinical outcomes were… More >

SHAOFENG XIONG^1,2, WENKAI LV³, GUOSHENG CAO⁴, LONGSHENG FU¹, WEN LIU³, MENGFAN LEI², YANNI LV^1,5,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

Danping Niu¹, Yuan Ping^1,*, Chun Guo², Xiaojun Wang³, Bin Hao⁴

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073630 - 12 January 2026

Abstract With the increasing complexity of malware attack techniques, traditional detection methods face significant challenges, such as privacy preservation, data heterogeneity, and lacking category information. To address these issues, we propose Federated Dynamic Prototype Learning (FedDPL) for malware classification by integrating Federated Learning with a specifically designed K-means. Under the Federated Learning framework, model training occurs locally without data sharing, effectively protecting user data privacy and preventing the leakage of sensitive information. Furthermore, to tackle the challenges of data heterogeneity and the lack of category information, FedDPL introduces a dynamic prototype learning mechanism, which adaptively adjusts the More >

Yi Feng^1,#, Haoxin Yang², Guicai Liang¹, Jun Chen³, Tao Li¹, Yingjuan Wang⁴, Jilin Chang¹, Yan Li³, Meng Yang¹, Xilong Zhou¹, Zhiqiang Wang^5,*, Chunlei Ge^1,*

Oncology Research, Vol.33, No.12, pp. 3801-3836, 2025, DOI:10.32604/or.2025.067824 - 27 November 2025

Abstract Immune checkpoint inhibitor (ICI) has limited efficacy in the treatment of immune “cold” tumors. Due to insufficient T cell infiltration and heterogeneous programmed death ligand 1 (PD-L1) expression, the ORR is only 5%–8% compared with 30%–40% of “hot” tumors. This article reviews the synergistic mechanism, clinical efficacy and optimization strategy of oncolytic virus (OVs) combined with ICIs in the treatment of refractory malignant tumors. Systematic analysis of mechanistic interactions across tumor types and clinical trial data demonstrates that OVs transform the immunosuppressive microenvironment by inducing immunogenic cell death and activating innate immunity. Concurrently, ICIs enhance… More >

Junyu Deng^1,2, Rui Zhang^1,*, Xudong Zhao³, Hongzhi Xu^1,2, Peng Ji¹, Zizhen Zhang¹, Yifan Yang¹

Energy Engineering, Vol.122, No.10, pp. 4153-4168, 2025, DOI:10.32604/ee.2025.065906 - 30 September 2025

Abstract Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction. Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments. However, the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood. In this study, a multiphase, multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments, incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea. The effects… More >

Lachezar Filchev^1,*, Milen Chanev¹, Galin Petrov²

Revue Internationale de Géomatique, Vol.34, pp. 513-533, 2025, DOI:10.32604/rig.2025.064280 - 06 August 2025

Abstract This review article provides a comprehensive analysis of Earth Observation (EO) applications for soil health assessment in Europe and abroad. The study explores the effectiveness of EO in capturing contextual information about various soil properties and conditions, as well as its role in monitoring soil health over time. The authors examine the current state of operational, semi-operational, and developing EO products and services relevant to soil health indicators. These include vegetation cover, forest cover, soil organic carbon, soil structure, landscape heterogeneity, and the presence of soil pollutants, excess nutrients, and salts. The review identifies gaps… More > Graphic Abstract

Yajie Bai^1,*, Jian Hou^2,3, Yongge Liu^2,3

Energy Engineering, Vol.122, No.6, pp. 2503-2518, 2025, DOI:10.32604/ee.2025.063198 - 29 May 2025

Abstract Natural gas hydrate widely exists in the South China Sea as clean energy. A three-phase transition layer widely exists in low permeability Class I hydrates in the Shenhu offshore area. Therefore, taking into account the low-permeability characteristics with an average permeability of 5.5 mD and moderate heterogeneity, a 3-D geological model of heterogeneous Class I hydrate reservoirs with three-phase transition layers is established by Kriging interpolation and stochastic modeling method, and a numerical simulation model is used to describe the depressurization production performance of the reservoir. With the development of depressurization, a specific range of… More >