Jiangxia Han^1,2, Liang Xue^1,2,*, Ying Jia³, Mpoki Sam Mwasamwasa^1,2, Felix Nanguka⁴, Charles Sangweni⁵, Hailong Liu³, Qian Li³

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1323-1340, 2024, DOI:10.32604/cmes.2023.031093 - 17 November 2023

Abstract Recent advances in deep neural networks have shed new light on physics, engineering, and scientific computing. Reconciling the data-centered viewpoint with physical simulation is one of the research hotspots. The physics-informed neural network (PINN) is currently the most general framework, which is more popular due to the convenience of constructing NNs and excellent generalization ability. The automatic differentiation (AD)-based PINN model is suitable for the homogeneous scientific problem; however, it is unclear how AD can enforce flux continuity across boundaries between cells of different properties where spatial heterogeneity is represented by grid cells with different… More >

Shuyu Wang¹, Linjuan Wang^1,*, Yunteng Wang²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09217

Abstract Material heterogeneity plays an important role in the blasting induced rock fracture. However, the investigation of the effects of material heterogeneity is limited by the numerical methods for dynamic fracture. In the work, we propose a peridynamic model for brittle rock with heterogeneous micro-modulus and critical stretch to investigate the effects of material heterogeneity on the blast-induced rock crack initiation and propagation. The discretization in polar coordinates is introduced into the proposed model to avoid the fallacious directional guidance to the crack initiation around the hole. The proposed model satisfies the More >

DONGYE YANG^1,#,*, DONGDONG GUO^2,3,#, YUNMEI PENG², DONGMENG LIU¹, YANQIU FU¹, FEN SUN², LISHI ZHOU¹, JIAQI GUO¹, LAIQING HUANG^2,3,*

BIOCELL, Vol.47, No.9, pp. 2037-2049, 2023, DOI:10.32604/biocell.2023.028863 - 28 September 2023

Abstract Introduction: Sulfatase 2 (SULF2), an endogenous extracellular sulfatase, can remove 6-O-sulfate groups of glucosamine residues from heparan sulfate (HS) chains to modulate the Wnt/β-catenin signaling pathway, which plays an important role in both liver carcinogenesis and embryogenesis. Side population (SP) cells are widely identified as stem-like cancer cells and are closely related to carcinoma metastasis, recurrence, and poor patient prognosis. However, the roles of SULF2 in SP cells of hepatomas are unclear, and the underlying mechanism is undefined. Objectives: This study aimed to compare the heterogeneity between SP cells and non-side population (NSP) cells derived from… More > Graphic Abstract

XIAOFENG LI¹, JINYANG ZHENG², JINFENG ZHU³, XIN HUANG⁴, HUANHUAN ZHU⁵, BINGDI CHEN^6,*

BIOCELL, Vol.47, No.8, pp. 1771-1781, 2023, DOI:10.32604/biocell.2023.028343 - 28 August 2023

Abstract Circulating tumor cells (CTCs) are neoplastic cells that are detached from primary tumors and enter circulation. Enumeration and characterization of CTCs are of significance in cancer diagnosis, prognosis, and treatment monitoring. CTC survival in the bloodstream is a limiting step for the development of metastases in distant organs. Recent technological advances, especially in single-cell molecular analyses have uncovered heterogeneous CTC survival mechanisms. Undergoing epithelial-to-mesenchymal transition (EMT), increasing stem cell-like properties, and forming cell clusters enable CTCs to adapt to the harsh microenvironment of the circulation. Expressing and releasing several immunosuppressive molecules help CTCs escape from More >

MUHAMMAD BABAR KHAWAR^1,2,3,#, YAJUN WANG^4,#, ANEEQA MAJEED³, ALI AFZAL⁵, KABEER HANEEF⁶, HAIBO SUN^1,2,*

Oncology Research, Vol.31, No.5, pp. 677-688, 2023, DOI:10.32604/or.2023.029718 - 21 July 2023

Abstract Hepatocellular carcinoma, the most common primary liver cancer and a leading cause of death, is a difficult disease to treat due to its heterogeneous nature. Traditional models, such as 2D culture and patient-derived xenografts, have not proven effective. However, the development of 3D culture techniques, such as organoids, which can mimic the tumor microenvironment (TME) and preserve heterogeneity and pathophysiological properties of tumor cells, offers new opportunities for treatment and research. Organoids also have the potential for biomarker detection and personalized medication, as well as genome editing using CRISPR/Cas9 to study the behavior of certain More > Graphic Abstract

Tao Liu¹, Kejia Zhang^1,*, Jingsong Yin¹, Yan Zhang¹, Zihao Mu¹, Chunsheng Li¹, Yanan Hu²

Computer Systems Science and Engineering, Vol.47, No.2, pp. 2563-2582, 2023, DOI:10.32604/csse.2023.041228 - 28 July 2023

Abstract Spatio-temporal heterogeneous data is the database for decision-making in many fields, and checking its accuracy can provide data support for making decisions. Due to the randomness, complexity, global and local correlation of spatiotemporal heterogeneous data in the temporal and spatial dimensions, traditional detection methods can not guarantee both detection speed and accuracy. Therefore, this article proposes a method for detecting the accuracy of spatiotemporal heterogeneous data by fusing graph convolution and temporal convolution networks. Firstly, the geographic weighting function is introduced and improved to quantify the degree of association between nodes and calculate the weighted… More >

Longlong Bai^1,#, Yong Zhang^2,#, Min Wang¹, Ying He¹, Tao Ye¹, Keli Zhao^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2221-2233, 2022, DOI:10.32604/phyton.2022.021422 - 30 May 2022

Abstract Chinese Torreya grandis (Torreya grandis cv. Merrillii) is a unique economic tree species in China. Intensive management related to application of chemical fertilizer and herbicides caused serious soil quality degradation of Chinese Torreya grandis plantations. Totally, 120 soil samples were collected from the main disbtributed areas of Chinese Torreya grandis in Southeastern China. In this area, soil pH values varied from 3.68 to 6.78, with a median value of 4.91, implying a trend of acidification. The average concentrations of organic matter, available nitrogen, available phosphorus and available potassium were 27.52 g kg⁻¹, 135.77 mg kg⁻¹, 15.12 mg kg⁻¹, and 153.43 mg kg⁻¹, More >

Kang Liu, Yanqiao Wang^*

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.1, pp. 119-135, 2022, DOI:10.32604/cmes.2022.018134 - 24 January 2022

Abstract Soil slope stability in seasonally frozen regions is a challenging problem for geotechnical engineers. The freeze-thaw process of soil slope caused by the temperature fluctuation increases the difficulty in predicting the slope stability because the soil property is influenced by the freeze-thaw cycle. In addition, the frozen soil, which has ice crystal, ice lens and experienced freeze-thaw process, could present stronger heterogeneity. Previous research has not investigated the combined effect of soil heterogeneity and freeze-thaw cycle. This paper studies the influence of soil heterogeneity on the stability of frozen soil slope under freeze-thaw cycles. The… More >

M. N. Tarhuni^1,*, W. R. Sulaiman¹, M. Z. Jaafar¹, K. M. Sabil²

Energy Engineering, Vol.119, No.1, pp. 253-273, 2022, DOI:10.32604/EE.2022.017820 - 22 November 2021

Abstract The X field is located in the southwestern part of block NX89 of Kentan Basin in Libya. This field is produced from Hailan multilayer consolidated sandstone with moderate rock property and a relatively low energy supplying. The reserve of subsurface energy sources is declining with years. Therefore, techniques were combined to achieve the energy optimization and increase hydrocarbon recovery. In order to understand the subsurface formation of the reservoir and facilitate oil production, global hydraulic element technique was used to quantify the reservoir rock types. In addition, stratigraphic modified Lorenz plot was used for reservoir… More >

Jie Li¹, Ziyu Zhou², Yun Chen², Qiusheng Yang^1,*, Carlos Alberto Busso^3,*

Phyton-International Journal of Experimental Botany, Vol.90, No.6, pp. 1633-1644, 2021, DOI:10.32604/phyton.2021.016795 - 28 June 2021

Abstract The spatial-temporal variation of understory light availability has important influences on species diversity and community assembly. However, the distribution characteristics and influencing factors of understory light availability have not been fully elucidated, especially in temperate deciduous, broad-leaved forests. In this study, the understory light availability was monitored monthly (May–October) in a temperate deciduous, broad-leaved forest in Henan Province, China. Differences in the light availability among different months and habitat types were statistically analyzed using Kruskal–Wallis method, respectively. Partial least squares path modeling (PLS-PM) was used to explore the direct and/or indirect effects of stand structure,… More >