Wen JING1,§, Chuanfen LI2,3,§, Yingli LU4, Lianshi FENG4
BIOCELL, Vol.43, No.3, pp. 129-138, 2019, DOI:10.32604/biocell.2019.06087
Abstract This study aimed to investigate the microRNA expression profile and the characteristics of lipid metabolism
in the livers of rats undergoing a high-fat diet. Fifty male Sprague-Dawley (SD) rats were divided into a standard chow
group (C group, N = 10) and a high-fat diet group (H group, N = 40). After 12 weeks, the rat body weight, body length,
fat mass, and serum lipid concentration were measured. The expression profile of microRNAs and the gene and protein
expression levels involved in lipid metabolism in rat liver were detected. Body fat and serum lipid concentrations
were all significantly higher in… More >
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