HAIFENG WANG1,2, KAI WANG1, JUAN GUO1, TIEQIAO WEN2
BIOCELL, Vol.43, No.2, pp. 59-64, 2019, DOI:10.32604/biocell.2019.05731
Abstract Histone deacetylation is a key modulator involved in cell proliferation, apoptosis, and mRNA transcription.
However, the effects of histone deacetylation on C17.2 neural stem cells (NSCs) remain unclear. Here, the histone
deacetylase inhibitors nicotinamide and trichostatin A (TSA) were used to determine the role of histone deacetylation
on gene transcription in NSCs. The results showed that the mRNA expression of p53, Sox1, Sox2, and Bax were
significantly higher in E14.5 NSCs than in C17.2 NSCs. Nestin, a marker gene of neuronal differentiation, did not differ
significantly between E14.5 NSCs and C17.2 NSCs. The transcription levels of p53 and Nestin were… More >
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