Entsar A. SAAD1, Reda S. EL-DEMERDASH2, Eman M. ABD EI-FATTAH1
BIOCELL, Vol.43, No.2, pp. 73-80, 2019, DOI:10.32604/biocell.2019.07020
Abstract Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to
evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction
of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10
(IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal
kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney
function tests. Rats treated with cisplatin + captopril showed noticeable kidney histopathological changes. Superior… More >
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