Wei LI, Huihui GAO, Ran TAO, Lifang LIU, Shiqiang SHANG*
BIOCELL, Vol.43, No.4, pp. 285-291, 2019, DOI:10.32604/biocell.2019.08177
Abstract As a response factor of interferon, tripartite motif (TRIM) 22 was reported to exert antiviral activity against
viruses. In this study, THP-1 macrophages were infected with human cytomegalovirus (HCMV) to establish the HCMV
lytic infection model. The mRNA levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and interferonbeta
(IFN-β) were significantly up-regulated in THP-1 macrophages at different infection time and titers. Moreover,
for the first time, upregulation of TRIM22 expression was found during HCMV infection at both mRNA and protein
levels in THP-1 macrophages. Furthermore, IFN-β could induce TRIM22 expression in THP-1 macrophages or HCMV
infected THP-1 macrophages. Depletion of… More >
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