Xihe TANG1,2, Meigang YU3, Rui HUANG2, Shengyong LAN2,*; Yimin FAN1,*
BIOCELL, Vol.44, No.1, pp. 13-18, 2020, DOI:10.32604/biocell.2020.07593
Abstract Human-induced neural stem cells (iNSCs) transplantation is a potential treatment of neurodegeneration
diseases. However, whether the reprogrammed cells have the same characterizations as human fetal neural stem cells
needs further exploration. Here we isolated human fetal neural stem cells from aborted 12-week fetal brains and
compared with iNSCs reprogrammed from human peripheral blood mononuclear cells in gene expression, proliferation
ability, differentiation capacity, and the responses to tumor necrosis factor-α. We found that iNSCs and NSCs both
expressed neural stem cell markers Nestin, SOX1, and SOX2. However, only iNSCs can be patterned into dopaminergic
neurons and motor neurons. Furthermore, both iNSCs… More >
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