MARGARIDA LORIGO^1,2, ELISA CAIRRAO^1,2,*

BIOCELL, Vol.46, No.6, pp. 1383-1389, 2022, DOI:10.32604/biocell.2022.018895

Abstract Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. The knowledge and understanding of CVD are based on the study of vascular physiology and how the smooth muscle cells and tissues perform their different functions. Exposure to endocrine disruptors (EDCs), such as phytoestrogens, polycyclic aromatic hydrocarbons, flame retardants, plasticizers, pesticides, and cosmetics, is an integral and fundamental part of human exposure. Humans are exposed to EDCs by multiple pathways including air, food, water, and consumer products. However, this exposure can lead to several adverse effects on human health, including on the cardiovascular (CV) system. The negative impact… More >

ANA ROCÍO ROLDÁN PALOMO¹, PEDRO MARTÍN¹, ALEJANDRO REBOLLEDO^1*, NICOLÁS ENRIQUE¹, LUIS E. FLORES², VERÓNICA MILESI¹

BIOCELL, Vol.36, No.2, pp. 73-81, 2012, DOI:10.32604/biocell.2012.36.073

Abstract After depletion of intracellular Ca²⁺ stores the capacitative response triggers an extracellular Ca²⁺ influx through store-operated channels (SOCs) which refills these stores. Our objective was to explore if human umbilical artery smooth muscle presented this response and if it was involved in the mechanism of serotonin- and histamine-induced contractions. Intracellular Ca²⁺ depletion by a Ca²⁺-free extracellular solution followed by Ca²⁺ readdition produced a contraction in artery rings which was inhibited by the blocker of Orai and TRPC channels 2-aminoethoxydiphenyl borate (2-APB), suggesting a capacitative response. In presence of 2-APB the magnitude of a second paired contraction by serotonin or histamine… More >