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    CASE REPORT

    Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation

    JOÃO OLIVEIRA PEREIRA1,2,*, JOÃO GAMA3, DIANA FERREIRA2,4, ARSÉNIO SANTOS2,4

    Oncology Research, Vol.29, No.2, pp. 81-85, 2021, DOI:10.32604/or.2022.023450

    Abstract Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor prognosis. Adenosquamous carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma and squamous cell components. We report the case of a 57-year-old male smoker who was admitted to the Emergency Room with skull and neck tumefactions, confusion and deteriorated general condition. The complementary study in the ER revealed severe hypercalcaemia (19.8 mg/dL), leukocytosis (18.7 × 109 /L) and extensive osteolytic lesions of the skull on cranioencephalic computer tomography (CT). The patient was stabilized and admitted. Thoracoabdominopelvic CT showed lung parenchyma consolidation with necrotic areas, supra… More >

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