YAPING WANG1,2,#,*; XIAOHONG XUE2,#; ZHEN ZHAO1,#; XIAOLIN LI2; ZHIYONG ZHU1
BIOCELL, Vol.46, No.7, pp. 1651-1659, 2022, DOI:10.32604/biocell.2022.018559
Abstract The pathogenesis of high altitude-related gastric mucosal injury remains poorly understood, this study aimed to
investigate the role of autophagy in hypoxia-induced apoptosis of rat gastric mucosal cells. Rats were randomized into
four groups which were maintained at an altitude of 400 m (P) or received no treatment (H), autophagy inducer
rapamycin (H+AI) or autophagy inhibitor 3-MA (H+AB) at an altitude of 4,300 m for 1, 7, 14 and 21 days,
respectively, and the morphology, ultrastructure, autophagy, and apoptosis of gastric mucosal tissues were examined.
Gastric mucosal epithelial cells CC-R039 were cultured under conditions of normoxia, 2% O2 (hypoxia), or… More >
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