Abdulrahman K. Sinno¹, Aisha Mustapha¹, Navya Nair¹, Simona Zaami², Lina De Paola², Valentina Billone³, Eleonora Conti³, Giuseppe Gullo^3,*, Pasquale Patrizio⁴

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072176 - 30 December 2025

Abstract Cervical cancer related to human papillomavirus (HPV) is a leading cause of cancer-related mortality among women worldwide. Cancer cells release fragments of their DNA, known as circulating tumor DNA (ctDNA), which can be detected in bodily fluids. A PubMed search using the terms “ctHPV” or “circulating tumor DNA” and “cervical cancer”, limited to the past ten years, identified 104 articles, complemented by hand-searching for literature addressing medico-legal implications. Studies were evaluated for relevance and methodological quality. Detection and characterization of circulating tumor HPV DNA (ctHPV DNA) have emerged as promising tools for assessing prognosis and More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Rabindranath Bera^1,#, Yotaro Ochi^2,3, Ying-Jung Huang¹, Ming-Chung Kuo^1,4, Kenichi Yoshida⁵, Seishi Ogawa², Lee-Yung Shih^1,4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070259 - 30 December 2025

Abstract Background: Breakpoint Cluster Region-Abelson (BCR::ABL1) fusion protein is essential in the pathogenesis of chronic myeloid leukemia (CML); however, the chronic-to-blast phase transformation remains elusive. We identified novel kinesin light chain 2 (KLC2) mutations in CML-myeloid blast phase patients. We aimed to examine the functional role of KLC2 mutations in leukemogenesis. Methods: To evaluate the biological role of KLC2 mutants (MT) in CML cells, we expressed KLC2-MT in different human CML cell lines harboring BCR::ABL1 and performed immunoblot, immunofluorescence, cell proliferation, differentiation, and apoptosis; Tyrosine kinase inhibitor (TKI)-drug activities; and clonogenic assays for in vitro functional analyses. We co-expressed KLC2-MT… More >

Kun Deng^1,2,3, Jianliang Huang^1,2,3, Danyang Li^2,3, Wei Gao^2,3, Minghua Wu^2,3,4,*, Mingsheng Lei^1,5,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069442 - 30 December 2025

Abstract Background: Glioblastoma (GBM) prognosis has seen little improvement over the past two decades. While immunotherapy has revolutionized cancer treatment, its impact on GBM remains limited. To characterize the evolving research landscape and identify future directions in GBM immunotherapy, we conducted a comprehensive bibliometric review. Methods: All literature related to immunotherapy in GBM from 1999 to 2024 was collected from the Web of Science Core Collection. CtieSpace and VOSviewer were used to conduct bibliometric analysis and visualize the data. Results: Bibliometric analysis identified 5038 publications authored by 23,335 researchers from 4699 institutions across 96 countries/regions, published in… More >

M. N. Abd-Al Ameer, Iman S. Kareem, Ali A. Ismaeel^*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.073437 - 27 December 2025

Abstract Electrical and electronic devices face significant challenges in heat management due to their compact size and high heat flux, which negatively impact performance and reliability. Conventional cooling methods, such as forced air cooling, often struggle to transfer heat efficiently. In contrast, thermoelectric coolers (TECs) provide an innovative active cooling solution to meet growing thermal management demands. In this research, a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases, in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems. This study evaluates the… More > Graphic Abstract

K. Naga Venkata Siva¹, Damodhar Reddy², P. Krishna Murthy³, Kiran Kumar Pulamolu⁴, M. Dharani⁵, T. Venkatakrishnamoorthy^6,*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.072982 - 27 December 2025

Abstract Conventional multilevel inverters often suffer from high harmonic distortion and increased design complexity due to the need for numerous power semiconductor components, particularly at elevated voltage levels. Addressing these shortcomings, this work presents a robust 15-level Packed U Cell (PUC) inverter topology designed for renewable energy and grid-connected applications. The proposed system integrates a sensor less proportional-resonant (PR) controller with an advanced carrier-based pulse width modulation scheme. This approach efficiently balances capacitor voltage, minimizes steady-state error, and strongly suppresses both zero and third-order harmonics resulting in reduced total harmonic distortion and enhanced voltage regulation. Additionally, More >

Mohammed Benamara^1,2, Boumediene Touati³, Said Bennaceur⁴, Bendjillali Ridha Ilyas^5,*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.072641 - 27 December 2025

Abstract This study explores the thin-layer convective solar drying of Marrubium vulgare L. leaves under conditions typical of sun-rich semi-arid climates. Drying experiments were conducted at three inlet-air temperatures (40°C, 50°C, 60°C) and two air velocities (1.5 and 2.5 m·s⁻¹) using an indirect solar dryer with auxiliary temperature control. Moisture-ratio data were fitted with eight widely used thin-layer models and evaluated using correlation coefficient (r), root-mean-square error (RMSE), and Akaike information criterion (AIC). A complementary heat-transfer analysis based on Reynolds and Prandtl numbers with appropriate Nusselt correlations was used to relate flow regime to drying performance, and an… More > Graphic Abstract

Samira Rastbod¹, Mehdi Jahangiri^2,*, Behrang Moradi¹, Haleh Nazari¹

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070089 - 27 December 2025

Abstract Curtain wall systems have evolved from aesthetic façade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness. This review presents a comprehensive examination of curtain walls from an energy-engineering perspective, highlighting their structural typologies (Stick and Unitized), material configurations, and integration with smart technologies such as electrochromic glazing, parametric design algorithms, and Building Management Systems (BMS). The study explores the thermal, acoustic, and solar performance of curtain walls across various climatic zones, supported by comparative analyses and iconic case studies including Apple Park, Burj Khalifa, and Milad Tower. Key challenges—including… More > Graphic Abstract

Heping Qi, Wenyao Sun^*, Yi Zhao, Xiaoyi Qian, Xingyu Jiang

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069603 - 27 December 2025

Abstract Virtual power plant (VPP) integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions, promote the consumption of renewable energy, and improve economic efficiency. In this paper, aiming at the uncertainty of distributed wind power and photovoltaic output, considering the coupling relationship between power, carbon trading, and green card market, the optimal operation model and bidding scheme of VPP in spot market, carbon trading market, and green card market are established. On this basis, through the Shapley value and independent risk contribution theory in cooperative game theory, the quantitative… More > Graphic Abstract

Jun Xiong^*, Peng Yang, Bohan Chen, Zeming Chen

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069438 - 27 December 2025

Abstract The reliable operation of power grid secondary equipment is an important guarantee for the safety and stability of the power system. However, various defects could be produced in the secondary equipment during long-term operation. The complex relationship between the defect phenomenon and multi-layer causes and the probabilistic influence of secondary equipment cannot be described through knowledge extraction and fusion technology by existing methods, which limits the real-time and accuracy of defect identification. Therefore, a defect recognition method based on the Bayesian network and knowledge graph fusion is proposed. The defect data of secondary equipment is… More >