Manaliben Amin^*

Journal on Artificial Intelligence, Vol.8, pp. 1-18, 2026, DOI:10.32604/jai.2026.073895 - 07 January 2026

Abstract Artificial intelligence (AI) is steadily making its way into pharmaceutical validation, where it promises faster documentation, smarter testing strategies, and better handling of deviations. These gains are attractive, but in a regulated environment speed is never enough. Regulators want assurance that every system is reliable, that decisions are explainable, and that human accountability remains central. This paper sets out a Human-in-the-Loop (HITL) AI approach for Computer System Validation (CSV) and Computer Software Assurance (CSA). It relies on explainable AI (XAI) tools but keeps structured human review in place, so automation can be used without creating… More >

Jie Li¹, Nan An^2,3, Youliang Ding^2,3,*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.072361 - 08 January 2026

Abstract Vehicle-induced response separation is a crucial issue in structural health monitoring (SHM). This paper proposes a block-wise sliding recursive wavelet transform algorithm to meet the real-time processing requirements of monitoring data. To extend the separation target from a fixed dataset to a continuously updating data stream, a block-wise sliding framework is first developed. This framework is further optimized considering the characteristics of real-time data streams, and its advantage in computational efficiency is theoretically demonstrated. During the decomposition and reconstruction processes, information from neighboring data blocks is fully utilized to reduce algorithmic complexity. In addition, a… More >

Longqi Liao¹, Jing Li², Yuhua Li³, Yuemin Wang³, Jinhua Li^1,*, Liyuan Cao^4,*, Chunxiang Li^4,*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.072237 - 08 January 2026

Abstract Quantitative detection of sleeve grouting compactness is a technical challenge in civil engineering testing. This study explores a novel quantitative detection method based on ultrasonic time-frequency dual-domain analysis. It establishes a mapping relationship between sleeve grouting compactness and characteristic parameters. First, this study made samples with gradient defects for two types of grouting sleeves, G18 and G20. These included four cases: 2D, 4D, 6D defects (where D is the diameter of the grouting sleeve), and no-defect. Then, an ultrasonic input/output data acquisition system was established. Three-dimensional sound field distribution data were obtained through an orthogonal… More >

Wu Feng^1,2,*, Tengku Anita Raja Hussin¹, Xu Yang³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071664 - 08 January 2026

Abstract This study investigates the thermo–mechanical behavior of C40 concrete and reinforced concrete subjected to elevated temperatures up to 700°C by integrating experimental testing and advanced numerical modeling. A temperature-indexed Concrete Damage Plasticity (CDP) framework incorporating bond–slip effects was developed in Abaqus to capture both global stress–strain responses and localized damage evolution. Uniaxial compression tests on thermally exposed cylinders provided residual strength data and failure observations for model calibration and validation. Results demonstrated a distinct two-stage degradation regime: moderate stiffness and strength reduction up to ~400°C, followed by sharp deterioration beyond 500°C–600°C, with residual capacity at… More >

Zhuangqiang Wen¹, Min Zhang², Zhekun Shou^3,*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071300 - 08 January 2026

Abstract Roadbed disease detection is essential for maintaining road functionality. Ground penetrating radar (GPR) enables non-destructive detection without drilling. However, current identification often relies on manual inspection, which requires extensive experience, suffers from low efficiency, and is highly subjective. As the results are presented as radar images, image processing methods can be applied for fast and objective identification. Deep learning-based approaches now offer a robust solution for automated roadbed disease detection. This study proposes an enhanced Faster Region-based Convolutional Neural Networks (R-CNN) framework integrating ResNet-50 as the backbone and two-dimensional discrete Fourier spectrum transformation (2D-DFT) for… More >

Weichen Wang¹, Shaofeng Wang¹, Wenjing Liu^1,*, Luncai Zhou², Erqing Zhang¹, Ting Gao³, Grigory Petrishin⁴

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071278 - 08 January 2026

Abstract In dry-coupled ultrasonic thickness measurement, thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy. Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise. This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference. By decomposing A-scan signals into Intrinsic Mode Functions (IMFs), the framework employs energy contribution thresholds (>85%) and kurtosis indices (>3) to autonomously select IMFs containing valid specimen echoes. Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing. More >

Jianhua Du¹, Shaofeng Wang¹, Ting Gao², Huiwen Sun², Wenjing Liu^1,*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071189 - 08 January 2026

Abstract In ultrasonic non-destructive testing of high-temperature industrial equipment, sound velocity drift induced by non-uniform temperature fields can severely compromise defect localization accuracy. Conventional approaches that rely on room-temperature sound velocities introduce systematic errors, potentially leading to misjudgment of safety-critical components. Two primary challenges hinder current methods: first, it is difficult to monitor real-time changes in sound velocity distribution within a thermal gradient; second, traditional uniform-temperature correction models fail to capture the nonlinear dependence of material properties on temperature and their effect on ultrasonic velocity fields. Here, we propose a defect localization correction method based on… More >

Renfei Chang¹, Liqiang Jin¹, Haihui Xie^2,*, Kai Zhang³, Musheng Ye⁴

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.063718 - 08 January 2026

Abstract To investigate the impact of temporary structures on the mechanical behavior of shaped bridge towers during the construction process, the Dianbu River Special Bridge was selected as the engineering background. A finite element model of the middle tower column during the construction stage was established using ABAQUS to analyze the effects of key parameters, including the angle and pretension of temporary cables, as well as the wall thickness and diameter of temporary diagonal braces. The study examines how these parameters influence the stresses at the tower-girder consolidation. The results indicate that the angle of temporary More >

Abdulrahman K. Sinno¹, Aisha Mustapha¹, Navya Nair¹, Simona Zaami², Lina De Paola², Valentina Billone³, Eleonora Conti³, Giuseppe Gullo^3,*, Pasquale Patrizio⁴

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072176 - 30 December 2025

Abstract Cervical cancer related to human papillomavirus (HPV) is a leading cause of cancer-related mortality among women worldwide. Cancer cells release fragments of their DNA, known as circulating tumor DNA (ctDNA), which can be detected in bodily fluids. A PubMed search using the terms “ctHPV” or “circulating tumor DNA” and “cervical cancer”, limited to the past ten years, identified 104 articles, complemented by hand-searching for literature addressing medico-legal implications. Studies were evaluated for relevance and methodological quality. Detection and characterization of circulating tumor HPV DNA (ctHPV DNA) have emerged as promising tools for assessing prognosis and More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >