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  • Open Access


    Impact of Exercise on Depression in Older Adults: Potential Benefits, Risks, and Appropriate Application Strategies

    Xingbin Du1,2, Jianda Kong3,*

    International Journal of Mental Health Promotion, Vol.26, No.5, pp. 345-350, 2024, DOI:10.32604/ijmhp.2024.049764

    Abstract As the global elderly population increases, depression within this group has become a significant public health concern. Although exercise has been recognized for its potential to improve depression in the elderly, the benefits, risks, and implementation strategies remain contentious. This review attempts to examine the impact of exercise on depression in older adults, including potential benefits, risks, and suggestions for application. Our analysis highlights the benefits of aerobic and resistance training, which can significantly alleviate depressive symptoms and enhance overall quality of life. Despite these benefits, the review acknowledges the complexity of the exercise-depression interaction More >

  • Open Access


    Association between Meeting 24-Hour Movement Guidelines and Psychological Features of Chinese Emerging Adults

    Yanjie Zhang1,2, Jin Kuang3, Xun Luo1,2, Mengxian Zhao4, Xiaolei Liu5,*

    International Journal of Mental Health Promotion, Vol.26, No.5, pp. 399-406, 2024, DOI:10.32604/ijmhp.2024.048925

    Abstract Background: Emerging adulthood is a pivotal life stage, presenting significant psychological and social changes, such as decreased sociability, depression, and other mental health problems. Previous studies have associated these changes with an unhealthy lifestyle. The 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual wellness. However, the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be explored. This cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics (self-exploration, instability, possibilities,… More >

  • Open Access


    Research on the Effect of Dance Therapy on Improving Social Communication Ability of Children with Autism

    Xiaorui Cui1, Shan Wang2,*

    International Journal of Mental Health Promotion, Vol.26, No.5, pp. 407-416, 2024, DOI:10.32604/ijmhp.2023.030135

    Abstract Research motivation: Through the 12 weeks dance therapy intervention for children with autism, the purpose is to explore the intervention model of dance therapy for children with autism and the changes in motor ability, social ability, and communication ability of children with autism after dance therapy intervention. The results of the research are expected to expand the intervention mode of dance therapy in my country and provide practical reference for rehabilitation intervention of children with autism. Research methods: 24 autistic boys aged 6 to 12 with mild to moderate symptoms were recruited and screened through the Internet… More >

  • Open Access


    Exploring the Reasons for Selfie-Taking and Selfie-Posting on Social Media with Its Effect on Psychological and Social Lives: A Study among Indian Youths

    Divya P. Vijayan1, Tokani Ghuhato1, Eslavath Rajkumar2,*, Allen Joshua George3, Romate John1, John Abraham4

    International Journal of Mental Health Promotion, Vol.26, No.5, pp. 389-398, 2024, DOI:10.32604/ijmhp.2024.023032

    Abstract ‘Selfie’ taking was introduced to the common people by smartphones and has become a common practice across the globe in no time. With technological advancement and the popularity of smartphones, selfie-taking has grown rapidly within a short time. In light of the new trend set by the generation, this study aimed to explore reasons for selfie-taking and selfie-posting on social media and their effects on the social and psychological lives of young adults. A purposive sampling method was adopted to select 20 Indian citizens, between 18 and 24 years. The data were collected through semi-structured More >

  • Open Access


    Knockdown of Histone Methyltransferase hSETD1A Inhibits Progression, Migration, and Invasion in Human Hepatocellular Carcinoma

    Xin-sheng Cheng*†, Shi-bo Sun*, Feng Zhong*, Kun He*, Jie Zhou*

    Oncology Research, Vol.24, No.4, pp. 239-245, 2016, DOI:10.3727/096504016X14648701448011

    Abstract Our aim was to study the expression of human SET domain containing protein 1A (hSETD1A) in hepatocellular carcinoma patients and its relationship with human hepatocellular carcinoma cell function. A total of 30 patients with hepatocellular carcinoma were enrolled in this study. The expression of hSETD1A was detected by real-time polymerase chain reaction (PCR) and Western blotting. The immortalized normal human liver cell line including SMMC-7721 was subjected to real-time PCR for hSETD1A mRNA. Furthermore, hSETD1A-small hairpin RNA (shRNA) was used to knock down hSETD1A expression in SMMC-7721 cells. Cell proliferation, cell apoptosis, and cell migration More >

  • Open Access


    The Downregulation of MicroRNA-10b and its Role in Cervical Cancer

    Dongling Zou*, Qi Zhou, Dong Wang, Lili Guan*, Li Yuan*†, Shaolin Li*

    Oncology Research, Vol.24, No.2, pp. 99-108, 2016, DOI:10.3727/096504016X14611963142173

    Abstract It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. However, the aberrant expression of miR-10b in cervical cancer and its possible role in cervical carcinogenesis was largely unknown. In this study, we investigated the expression of miR-10b in cervical cancer tissues, carcinoma in situ tissues, mild dysplasia, moderate dysplasia, severe dysplasia tissues, and normal controls. We found More >

  • Open Access


    Self-Reported Adherence to Capecitabine on XELOX Treatment as Adjuvant Therapy for Colorectal Cancer

    Kazuyoshi Kawakami*, Takashi Yokokawa*, Kazuo Kobayashi*, Takahito Sugisaki*, Kenichi Suzuki*, Mitsukuni Suenaga, Kensei Yamaguchi, Ayaka Inoue, Yoshiaki Machida, Toshiharu Yamaguchi, Toshihiro Hama*

    Oncology Research, Vol.25, No.9, pp. 1625-1631, 2017, DOI:10.3727/096504017X15012905098071

    Abstract Adherence has become an important issue in modern oncology treatment. Most studies have included heterogeneous target tumor types, regimens, and therapy settings. Our study focused on capecitabine during capecitabine plus oxaliplatin (XELOX) treatment as an adjuvant therapy for colorectal cancer. The main aims of this study were to evaluate real-life adherence to capecitabine and to investigate candidate factors that might decrease adherence. We studied 338 consecutive patients who received XELOX treatment between December 1, 2011, and April 30, 2015, at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research. Our study assessed adherence… More >

  • Open Access


    Targeting CD47 Enhances the Efficacy of Anti-PD-1 and CTLA-4 in an Esophageal Squamous Cell Cancer Preclinical Model

    Hua Tao, Pudong Qian, Feijiang Wang, Hongliang Yu, Yesong Guo

    Oncology Research, Vol.25, No.9, pp. 1579-1587, 2017, DOI:10.3727/096504017X14900505020895

    Abstract Esophageal squamous cell cancer is a highly aggressive cancer with a dismal 5-year survival rate. CD47 is a cell transmembrane protein that is involved in cell apoptosis, proliferation, adhesion, migration, and antigen presentation in the immune system. By interacting with signal regulatory protein-a expressed in antigenpresenting cells (APCs), CD47 acts as an antiphagocytic mechanism to inhibit APC-dependent antigen presentation. Overexpression of CD47 was found in various types of cancer. However, its role in esophageal squamous cell cancer is not yet clear. Anti-CD47 is an antagonist of CD47 signaling pathways by competing with its ligand. In… More >

  • Open Access


    Clinical Value of Capecitabine-Based Combination Adjuvant Chemotherapy in Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials

    Guanling Chen1, Zhaoze Guo1, Minfeng Liu, Guangyu Yao, Jianyu Dong, Jingyun Guo, Changsheng Ye

    Oncology Research, Vol.25, No.9, pp. 1567-1578, 2017, DOI:10.3727/096504017X14897173032733

    Abstract Capecitabine has consistently demonstrated high efficacy and acceptable tolerability in salvage chemotherapy for advanced breast cancer. However, there remains no consensus on its role in adjuvant chemotherapy for early breast cancer (EBC). To estimate the value of capecitabine-based combination adjuvant treatment in EBC, eight randomized controlled trials with 14,072 participants were analyzed. The efficacy and safety outcomes included disease-free survival (DFS), overall survival (OS), relapse, breast cancer-specific survival (BCSS), and grades 3–5 adverse events. Capecitabine-based combination adjuvant chemotherapy demonstrated a 16% increase in BCSS (HR = 0.84, 95% CI = 0.71–0.98, p = 0.03) in the… More >

  • Open Access


    Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death

    Vesna Vetma*†‡, Jan Rožanc§, Emilie M. Charles*†, Christian T. Hellwig*†‡¶, Leonidas G. Alexopoulos§#, Markus Rehm*†‡#

    Oncology Research, Vol.25, No.9, pp. 1489-1494, 2017, DOI:10.3727/096504017X14897145996933

    Abstract Antagonists of inhibitors of apoptosis proteins (IAPs), alone or in combination with genotoxic therapeutics, have been shown to efficiently induce cell death in various solid tumors. The IAP antagonist birinapant is currently being tested in phase II clinical trials. We herein aimed to investigate the antitumor efficacy of dacarbazine in vitro, both as a single agent and in combination with birinapant, in melanoma cell lines. Covering clinically relevant drug concentration ranges, we conducted a total of 5,400 measurements in a panel of 12 human melanoma cell lines representing different stages of disease progression. Surprisingly, functionally More >

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