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  • Open Access

    ARTICLE

    Morpho-Anatomical and Biochemical Defense Responses of Pigeon Pea Varieties to Phytophthora Blight

    Kirti A. Yadav1, Yachana Jha1, Haiam O. Elkatry2, Heba I. Mohamed3,*, Ahmed Mahmoud Ismail4, Abdelrahman R. Ahmed2,*

    Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.074570 - 30 January 2026

    Abstract Phytophthora blight is a devastating disease of pigeon pea (Cajanus cajan) that severely impacts plant growth and productivity. This study investigates the morphological, anatomical, and biochemical responses of a susceptible variety (ICPL 11260) and a resistant variety (IPAC-02) following infection by Phytophthora. Morphological analyses showed that infection caused a drastic reduction in root length, shoot length, leaf number, fresh weight, and dry weight in the susceptible ICPL 11260 variety, with reductions ranging from 0.5- to 2-fold compared to non-infected controls. Anatomical observations revealed pronounced cellular damage and mycelial invasion in infected ICPL 11260 plants by 30… More >

  • Open Access

    ARTICLE

    Salicylic Acid-Elicited Alkaloid Accumulation in Pinellia ternata Microtubers: Cytotoxicity and Transcriptomic Analysis

    Xiaoqing Jiang1,2,#, Pengchong Li1,2,#, Hongchuang Liu1,2, Wenjie Dong1,2, Wenjing Liu1,2, Di Wu1,2, Jianping Xue1,2, Fenglan Zhao1,2,*, Yongbo Duan1,2,*

    Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.074434 - 30 January 2026

    Abstract As its tuberous alkaloids induce valuable pharmacological effects, Pinellia ternata has considerable clinical value. However, its production currently fails to meet its demand. In vitro microtuber culture, combined with salicylic acid (SA) elicitation, may provide an effective alternative to traditional field production. In this study, an in vitro P. ternata microtuber induction system was developed and used to evaluate SA-induced elicitation of alkaloid accumulation. The quality of in vitro microtubers was assessed by total alkaloid measurement, a cytotoxicity assay, and transcriptomic analysis. With or without SA treatment, P. ternata microtuber induction was achieved within 60 d using petiole-derived explants, with… More >

  • Open Access

    REVIEW

    Targeting Sphingolipids in Breast Cancer: From Tumor Biology to Therapeutic Strategies

    Min Hee Kim1, Boyoon Huh1, Joo-Won Park1,*, Woo-Jae Park2,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071523 - 19 January 2026

    Abstract Breast cancer is one of the most prevalent malignancies among women and comprises a heterogeneous spectrum of molecular subtypes with distinct biological behaviors. Among various regulatory molecules, sphingolipids play pivotal roles in dynamically modulating fundamental cellular processes such as proliferation, apoptosis, and metastasis through metabolic interconversions, including phosphorylation, glycosylation, and the generation of sphingosine-1-phosphate. This review aims to elucidate the mechanisms through which sphingolipid metabolism orchestrates cancer cell fate and drives breast cancer progression. Particular emphasis is placed on the balance between proapoptotic ceramides and pro-survival metabolites, such as sphingosine-1-phosphate, which collectively influence tumor growth More >

  • Open Access

    ARTICLE

    A Decentralized Identity Framework for Secure Federated Learning in Healthcare

    Samuel Acheme*, Glory Nosawaru Edegbe

    Journal of Cyber Security, Vol.8, pp. 1-31, 2026, DOI:10.32604/jcs.2026.073923 - 07 January 2026

    Abstract Federated learning (FL) enables collaborative model training across decentralized datasets, thus maintaining the privacy of training data. However, FL remains vulnerable to malicious actors, posing significant risks in privacy-sensitive domains like healthcare. Previous machine learning trust frameworks, while promising, often rely on resource-intensive blockchain ledgers, introducing computational overhead and metadata leakage risks. To address these limitations, this study presents a novel Decentralized Identity (DID) framework for mutual authentication that establishes verifiable trust among participants in FL without dependence on centralized authorities or high-cost blockchain ledgers. The proposed system leverages Decentralized Identifiers (DIDs) and Verifiable Credentials… More >

  • Open Access

    REVIEW

    Branched-Chain Amino Acid Metabolic Reprogramming and Cancer: Molecular Mechanisms, Immune Regulation, and Precision Targeting

    Dongchi Cai1,2,#, Jialin Ji3,#, Chunhui Yang1,*, Hong Cai1,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

    Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

  • Open Access

    ARTICLE

    Artificial Neural Network Model for Thermal Conductivity Estimation of Metal Oxide Water-Based Nanofluids

    Nikhil S. Mane1, Sheetal Kumar Dewangan2,*, Sayantan Mukherjee3, Pradnyavati Mane4, Deepak Kumar Singh1, Ravindra Singh Saluja5

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-16, 2026, DOI:10.32604/cmc.2025.072090 - 10 November 2025

    Abstract The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids. Researchers rely on experimental investigations to explore nanofluid properties, as it is a necessary step before their practical application. As these investigations are time and resource-consuming undertakings, an effective prediction model can significantly improve the efficiency of research operations. In this work, an Artificial Neural Network (ANN) model is developed to predict the thermal conductivity of metal oxide water-based nanofluid. For this, a comprehensive set of 691 data points was collected from the literature. This dataset is split More >

  • Open Access

    ARTICLE

    Towards Decentralized IoT Security: Optimized Detection of Zero-Day Multi-Class Cyber-Attacks Using Deep Federated Learning

    Misbah Anwer1,*, Ghufran Ahmed1, Maha Abdelhaq2, Raed Alsaqour3, Shahid Hussain4, Adnan Akhunzada5,*

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-15, 2026, DOI:10.32604/cmc.2025.068673 - 10 November 2025

    Abstract The exponential growth of the Internet of Things (IoT) has introduced significant security challenges, with zero-day attacks emerging as one of the most critical and challenging threats. Traditional Machine Learning (ML) and Deep Learning (DL) techniques have demonstrated promising early detection capabilities. However, their effectiveness is limited when handling the vast volumes of IoT-generated data due to scalability constraints, high computational costs, and the costly time-intensive process of data labeling. To address these challenges, this study proposes a Federated Learning (FL) framework that leverages collaborative and hybrid supervised learning to enhance cyber threat detection in… More >

  • Open Access

    ARTICLE

    Laser-Ablated CdS and Ag2O Nanomaterials for High-Sensitivity Photodetectors

    Hameed H. Ahmed1, Thaer A. Mezher2,*, Marwan R. Rashid3

    Chalcogenide Letters, Vol.22, No.12, pp. 1055-1066, 2025, DOI:10.15251/CL.2025.2212.1055 - 10 December 2025

    Abstract Laser ablation in liquids (LAL), a hygienic and effective method for creating high-purity nanomaterials, was used in this study to create cadmium sulfide (CdS) and silver oxide (Ag2O) nanoparticles. The sputtering process was used to deposit the produced nanomaterials on porous silicon (PSi) substrates, and a number of assays were used to examine the samples’ structural, optical, and electrical characteristics. The CdS sample had a hexagonal crystal structure, according to X-ray diffraction (XRD) data, whereas the AgO sample had a cubic structure. The diameters of the nanoparticles in the two samples ranged from 22.64 nm for… More >

  • Open Access

    ARTICLE

    Pills as Aids? Substance Use, School Satisfaction, Sleep Quality, Body Image, and Mental Well-Being Among Korean Adolescents

    Wufan Jia1, Seung Hee Yoo2, Hye Eun Lee3,*

    International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1897-1906, 2025, DOI:10.32604/ijmhp.2025.071572 - 31 December 2025

    Abstract Background: With growing concerns about the abuse of prescription and over-the-counter (OTC) medications, such as medications for attention-deficit/hyperactivity disorder (ADHD), diet pills, and sleep aids, among adolescents in South Korea, this study aimed to investigated how these substances affect key aspects of adolescent well-being, specifically school satisfaction, body image, and sleep quality, and their association with mental health outcomes. Methods: A two-wave longitudinal survey was conducted with Korean female high school students (Wave 1: n = 494; Wave 2: n = 189). Linear regression analyses were used to evaluate the effects of ADHD medications, diet pills, and… More >

  • Open Access

    ARTICLE

    Phytochemical Composition and Pharmacological Effects of Extracts from Gilia capitata Sims

    Oleh Koshovyi1, Amal D. Premarathna2, Rando Tuvikene2, Valdas Jakštas3,4, Vaidotas Žvikas3, Yurii Hrytsyk5, Lyubov Grytsyk5, Andriy Grytsyk5, Jaan Liira6, Ain Raal1,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3991-4019, 2025, DOI:10.32604/phyton.2025.074153 - 29 December 2025

    Abstract Gilia capitata Sims (Polemoniaceae) is an annual herbaceous plant widely distributed in western North America and cultivated as an ornamental flower. The detailed chemical composition and pharmacological properties of this plant have not been previously reported. This study aimed to investigate the chemical composition and pharmacological activity of aqueous-ethanolic extracts derived from different plant parts (herb, flowers, stems, roots, and fruits). HPLC analysis identified 12 phenolic compounds and 16 amino acids in the aqueous-ethanolic extracts obtained from these plant parts. The biological effects of the extracts were evaluated in vitro, including cytotoxicity, anti-inflammatory response, and wound-healing potential.… More >

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