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  • Open Access


    Comparison of Apigenin, Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves, Embryogenic Cultures and Cell Suspension Cultures of Parsley (Petroselinum crispum)

    Laura Isabel Arias-Rodríguez1, Martha Alicia Rodríguez-Mendiola2,*, Carlos Arias-Castro2,*, Federico Antonio Gutiérrez Miceli1, Diana Reséndez Pérez3, María Celina Luján Hidalgo1, Juan José Villalobos Maldonado1, Norma Alejandra Mancilla Margalli2

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2807-2823, 2023, DOI:10.32604/phyton.2023.030396

    Abstract In recent years, there has been a growing interest in exploring alternative treatments for bone defects. Bone tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone regeneration. In our study, we specifically investigated the extract of Petroselinum crispum, a plant known for its abundance of osteogenic flavonoids such as apigenin, quercetin, and kaempferol. Our objective was to compare the total flavonoid content (TFC) and their accumulation in different sources. We obtained hydrolyzed aqueous extracts from the leaves of parsley plants (grown for 12 weeks in the field), weekly embryogenic cultures, and suspension… More >

  • Open Access


    First Report of a Successful Development of Yam Hybrids (Dioscorea alata L.) from Lyophilized and Long-Term Stored Pollens

    Erick Malédon1, Elie Nudol1, Christophe Perrot1, Marie-Claire Gravillon1, Ronan Rivallan2,3, Denis Cornet2, Hâna Chair2,3, Komivi Dossa1,2,3,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2861-2874, 2023, DOI:10.32604/phyton.2023.042397

    Abstract Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding programs. Therefore, pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic gains. This 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam hybrids. Fresh pollens were collected from two Dioscorea alata males, then lyophilized (two lyophilization treatments were applied), followed by storage at room temperature (24°C–25°C) for 12 months. Moreover, the lyophilized and stored pollens were tested for viability by crossing with four… More >

  • Open Access


    FIDS: Filtering-Based Intrusion Detection System for In-Vehicle CAN

    Seungmin Lee, Hyunghoon Kim, Haehyun Cho, Hyo Jin Jo*

    Intelligent Automation & Soft Computing, Vol.37, No.3, pp. 2941-2954, 2023, DOI:10.32604/iasc.2023.039992

    Abstract Modern vehicles are equipped with multiple Electronic Control Units (ECUs) that support various convenient driving functions, such as the Advanced Driver Assistance System (ADAS). To enable communication between these ECUs, the Controller Area Network (CAN) protocol is widely used. However, since CAN lacks any security technologies, it is vulnerable to cyber attacks. To address this, researchers have conducted studies on machine learning-based intrusion detection systems (IDSs) for CAN. However, most existing IDSs still have non-negligible detection errors. In this paper, we propose a new filtering-based intrusion detection system (FIDS) to minimize the detection errors of machine learning-based IDSs. FIDS uses… More >

  • Open Access


    A Thermo-Chemo-Mechanically Coupled Peridynamic Model for Investigating the Crack Behaviors of Deformable Solids with Heat Conduction, Species Diffusion, and Chemical Reactions

    Yu Xiang1, Bao Qin2, Zheng Zhong1,*, Zhenjun Jiao1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09088

    Abstract A thermo-chemo-mechanically (TCM) coupled peridynamic (PD) model is proposed to analyze the crack behavior in solids considering heat conduction, species diffusion, and chemical reactions. A PD theoretical framework is established based on non-equilibrium thermodynamics. The influences of species diffusion and chemical reactions on the Helmholtz free energy density and the subsequent formation and propagation of cracks are distinguished by introducing the concentration of diffusive species and the extent of the chemical reaction. Furthermore, inter-physics coupling coefficients are calibrated by equating the corresponding field in the PD model to the continuum mechanics under the same condition. The cases of vacancy redistribution… More >

  • Open Access


    Fusion of Feature Ranking Methods for an Effective Intrusion Detection System

    Seshu Bhavani Mallampati1, Seetha Hari2,*

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 1721-1744, 2023, DOI:10.32604/cmc.2023.040567

    Abstract Expanding internet-connected services has increased cyberattacks, many of which have grave and disastrous repercussions. An Intrusion Detection System (IDS) plays an essential role in network security since it helps to protect the network from vulnerabilities and attacks. Although extensive research was reported in IDS, detecting novel intrusions with optimal features and reducing false alarm rates are still challenging. Therefore, we developed a novel fusion-based feature importance method to reduce the high dimensional feature space, which helps to identify attacks accurately with less false alarm rate. Initially, to improve training data quality, various preprocessing techniques are utilized. The Adaptive Synthetic oversampling… More >

  • Open Access


    A Local to Global (L2G) Finite Element Method for Efficient and Robust Analysis of Arbitrary Cracking in 2D Solids

    Zhaoyang Ma1,*, Qingda Yang1, Xingming Guo1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.08941

    Abstract P This paper presents and validates a new local to global (L2G) FEM approach that can analyze multiple, interactive fracture processes in 2D solids with improved numerical efficiency and robustness. The method features: 1) forming local problems for individual and interactive cracks; and 2) parallel solving local problems and returning local solutions as part of the trial solution for global iteration. It has been demonstrated analytically (through a simple 1D problem) and numerically (through several benchmarking examples) that, the proposed method can substantially improve the robustness of the global solution process and significantly reduce the costly global iteration for convergence.… More >

  • Open Access


    Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling


    BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093

    Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were analyzed by mitochondrial staining reagent… More >

  • Open Access


    Flexible Biofoams Based on Furanics and Fatty Acids Esterified Tannin

    Elham Azadeh1, Ummi Hani Abdullah2,3, Christine Gerardin1,*, Antonio Pizzi1,*, Philippe Gerardin1, Cesar Segovia4

    Journal of Renewable Materials, Vol.11, No.10, pp. 3625-3645, 2023, DOI:10.32604/jrm.2023.030373

    Abstract Water repellant, flexible biofoams using tannin esterified with various fatty acid chains, namely lauric, palmitic and oleic acids, by reaction with lauryl chloride, palmitoyl chloride, and oleyl chloride were developed and their characteristics compared with the equivalently esterified rigid biofoams. Glycerol, while initially added to control the reaction temperature, was used as a plasticizer yielding flexible biofoams presenting the same water repellant character that the equivalent rigid foams. Acetaldehyde was used as the cross-linking agent instead of formaldehyde, as it showed a better performance with the esterified tannin. The compression results showed a significant decrease of the Modulus of Elasticity… More >

  • Open Access


    Improving Intrusion Detection in UAV Communication Using an LSTM-SMOTE Classification Method

    Abdulrahman M. Abdulghani, Mokhles M. Abdulghani, Wilbur L. Walters, Khalid H. Abed*

    Journal of Cyber Security, Vol.4, No.4, pp. 287-298, 2022, DOI:10.32604/jcs.2023.042486

    Abstract Unmanned Aerial Vehicles (UAVs) proliferate quickly and play a significant part in crucial tasks, so it is important to protect the security and integrity of UAV communication channels. Intrusion Detection Systems (IDSs) are required to protect the UAV communication infrastructure from unauthorized access and harmful actions. In this paper, we examine a new approach for enhancing intrusion detection in UAV communication channels by utilizing the Long Short-Term Memory network (LSTM) combined with the Synthetic Minority Oversampling Technique (SMOTE) algorithm, and this integration is the binary classification method (LSTM-SMOTE). We successfully achieved 99.83% detection accuracy by using the proposed approach and… More >

  • Open Access


    Mini-organs with big impact: Organoids in liver cancer studies


    Oncology Research, Vol.31, No.5, pp. 677-688, 2023, DOI:10.32604/or.2023.029718

    Abstract Hepatocellular carcinoma, the most common primary liver cancer and a leading cause of death, is a difficult disease to treat due to its heterogeneous nature. Traditional models, such as 2D culture and patient-derived xenografts, have not proven effective. However, the development of 3D culture techniques, such as organoids, which can mimic the tumor microenvironment (TME) and preserve heterogeneity and pathophysiological properties of tumor cells, offers new opportunities for treatment and research. Organoids also have the potential for biomarker detection and personalized medication, as well as genome editing using CRISPR/Cas9 to study the behavior of certain genes and therapeutic interventions. This… More > Graphic Abstract

    Mini-organs with big impact: Organoids in liver cancer studies

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