KANWAL REHMAN1, AMMARA AFZAAL2, MUHAMMAD SAJID HAMID AKASH2,*, MUHAMMAD IMRAN3,4, MOHAMMED A. ASSIRI3,4
BIOCELL, Vol.47, No.4, pp. 809-823, 2023, DOI:10.32604/biocell.2023.025850
Abstract The cytokine channel’s mechanism for self-regulation involves the application of antagonistic cytokines that are synthesized to connect to the receptors and release soluble cytokine receptors. The very first receptor antagonist of cytokine that was naturally present was interleukin-1 receptor antagonist (IL-1Ra). The IL-1Ra protein forms are disinfected from supernatants of cultured monocytes on stacked IgG. The family of IL-1 consists of IL-1α, IL-1β and IL-1Ra. Human monocytes regulate the production of IL-Ra. IL-Ra takes part in normal physiological functions by using specific antibodies, and acts as an anti-inflammatory agent. IL-Ra is synthesized in the tissues during the period of active… More >
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