YUN SUN#, YI LIU#, BINHUA XUE, XIAODIE WANG, WEILI YU*
BIOCELL, Vol.45, No.1, pp. 129-138, 2021, DOI:10.32604/biocell.2021.013275
Abstract Hyperlipidemia acute pancreatitis (HLAP) is a significant cause of AP, characterized by recurrent attacks, more
complications and high incidence and mortality. HLAP is often accompanied by single or multiple organ damage.
Negative regulation of interferon-regulatory factor 9 (IRF9) on sirtuin-1 (SIRT1) contributes to a range of diseases.
However, the function of IRF9 and SIRT1, and the relationship of the two in HLAP with heart injury remain to be
illustrated so far. Animal models of HLAP were set up by feeding with high-fat chow and subsequently injecting 20%
L-arginine intraperitoneally. The degree of pancreas and heart tissue injury was evaluated. Heart… More >
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