Anjali Kariyarath Valappil1,#, Reshmi Akter2,#, Muhammad Awais2, Dong Uk Yang3, Daehyo Jung2, Li Ling4, Eun Kim5, Kyu Hyeong Yoon5, Yoon Ok Lee5, Deok Chun Yang1,2,4,*
BIOCELL, Vol.49, No.9, pp. 1771-1795, 2025, DOI:10.32604/biocell.2025.069145
- 25 September 2025
Abstract Objectives: The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery, particularly in cancer therapy. This study aimed to evaluate the cytotoxicity, apoptosis induction, and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus, Phragmites communis, and Pinus densiflora, as well as their combined extract (GMAS 01/COM), on human lung cancer cells (A549) and normal cell lines, including murine macrophages (RAW 264.7) and human keratinocytes (HaCaT). Methods: Plant extracts were prepared using aqueous extraction, sonication, and rotary evaporation. The total phenolic and flavonoid contents were quantified using the… More >
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