Bahram Barati1, Fatemeh Fazeli Zafar1, Shuanhu Hu1, Najmeh Fani2, Sajjad Eshtiaghi3, Shuang Wang1,*
Journal of Renewable Materials, Vol.9, No.11, pp. 1843-1857, 2021, DOI:10.32604/jrm.2021.016301
Abstract Enhancing the stability of biomolecules is one of the hot topics in industry. In this study, we enhanced the stability
of an important protein called LEPTIN. LEPTIN is a hormone secreted by fat cells playing an essential role in
body weight and composition, and its deficiency can result in several disorders. The treatment of related LEPTIN
dysfunctions is often available in the form of injection. To decrease the cost and the frequency of its applications
can be achieved by increasing its lifetime through engineering LEPTIN. In this study, to engineer LEPTIN, we
have introduced disulfide bonds. Disulfide By Design server… More >
Graphic Abstract
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