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    MicroRNA-98-5p Inhibits Cell Proliferation and Induces Cell Apoptosis in Hepatocellular Carcinoma via Targeting IGF2BP1

    Tinghui Jiang*, Mengfan Li, Qiuyin Li, Zhiqiang Guo§, Xianjun Sun, Xufeng Zhang§, Yan Liu, Wenyi Yao, Ping Xiao*

    Oncology Research, Vol.25, No.7, pp. 1117-1127, 2017, DOI:10.3727/096504016X14821952695683

    Abstract Some microRNAs (miRs) have been demonstrated to play promoting or tumor-suppressing roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-98-5p in HCC still remains largely unclear. In the present study, our data showed that miR-98-5p was significantly downregulated in 84 cases of HCC tissues compared to the matched adjacent nontumor tissues. In addition, downregulation of miR-98-5p was associated with tumor size, portal vein tumor embolus, node metastasis, and clinical stage in HCC. HCC patients with low expression of miR-98-5p showed a shorter survival time compared with those with… More >

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