Xiaoning Qin1, Liqing Yuan2, Hongxun Ruan1, Lin Lin1
BIOCELL, Vol.43, No.2, pp. 89-98, 2019, DOI:10.32604/biocell.2019.06352
Abstract Interleukin-22 (IL-22) is a member of IL-10 cytokine family which is expressed in activated T cells
predominantly and in activated natural killer cells at lower levels. Previous studies have demonstrated the link between
elevated levels of IL-22 and disease severity of psoriasis, Crohn’s disease, rheumatoid arthritis and interstitial lung
diseases. However, the function of IL-22 in the development and progression of colorectal cancer (CRC) remains
elusive. In this study, we first evaluated the IL-22/IL-22R1 level in CRC patients, and found that tumor tissues
have more active expression of IL-22 and IL-22R1 than normal tissues, presenting correlation with the degree of… More >
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