Lili Deng*1, Xue Yang†1, Jun Fan*, Yuedi Ding*, Ying Peng*, Dong Xu*, Biao Huang*‡, Zhigang Hu†
Oncology Research, Vol.28, No.6, pp. 579-590, 2020, DOI:10.3727/096504020X15942028641011
Abstract Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia
virus is being developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory
cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (IL-24) is an
important immune mediator, as well as a broad-spectrum tumor suppressor. We constructed a targeted vaccinia
virus of Guang9 strain harboring IL-24 (VG9-IL-24) to evaluate its antitumor effects. In vitro, VG9-IL-24
induced an increased number of apoptotic cells and blocked colorectal cancer cells in the G2
/M phase of the
cell cycle. VG9-IL-24 induced apoptosis in… More >
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