Anastasia S. Proskurina1, Alisa V. Spaselnikova1,2, Genrikh S. Ritter1,2, Evgenia V. Dolgova1, Ekaterina A. Potter1, Margarita V. Romanenko2, Sergey V. Netesov2, Yaroslav R. Efremov1,2, Oleg S. Taranov3, Nikolay A. Varaksin4, Tatiana G. Ryabicheva4, Aleksandr A. Ostanin5, Elena R. Chernykh5, Sergey S. Bogachev1
European Cytokine Network, Vol.30, No.2, pp. 43-58, 2019, DOI:10.1684/ecn.2019.0427
Abstract The present study demonstrates that monocyte-derived dendritic cells (moDCs) produced in vitro using a
GM-CSF and IFN-α differentiation protocol encompass a rare (~5%) subpopulation of cells showing classical
dendritic cell morphology and capable of natural internalization of extracellular self-DNA. We established that DEFB,
HMGB1, LL-37 and RAGE antigens, which mediate the process of DNA internalization, are expressed on the surface
of moDCs similar to plasmacytoid dendritic cells. However, in constrast to the latter subpopulation, these cells do not
produce interleukin (IL)-37. Nonetheless, the process of DNA internalization was not in direct relation to the presence… More >
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