Yongren Wu∗, Sarah Cisewski∗, Barton L. Sachs†, Hai Yao∗,†,‡
Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 159-182, 2013, DOI:10.3970/mcb.2013.010.159
Abstract This study examines the effects of cartilage endplate (CEP) calcification
and the injection of intervertebral disc (IVD) cells on the nutrition distributions
inside the human IVD under physiological loading conditions using multiphasic
finite element modeling. The human disc was modeled as an inhomogeneous mixture
consisting of a charged elastic solid, water, ions (Na+ and Cl−), and nutrient solute(oxygen,glucose and lactate) phases. The effect of the endplate calcification was simulated by a reduction of the tissue porosity (i.e., water volume faction) from 0.60 to 0.48. The effect of cell injection was simulated by increasing the cell density in the nucleus pulposus… More >
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