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    Anatomical Variations in Circle of Willis and Intracranial Aneurysm Formation

    Zhen Liu1, Yan Cai1, Guo-Zhong Chen2, Guang-Ming Lu, Zhi-Yong Li1,3,*

    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 19-31, 2017, DOI:10.3970/mcb.2017.014.019

    Abstract Background: Intracranial aneurysm (IA) can be commonly found in the circle of Willis (CoW), and a higher morbidity of IA is found to be associated with a higher percentage of an incomplete CoW. Hemodynamic factors are believed to play an important role in aneurysm formation. However, how the anatomical variations in CoW lead to hemodynamic difference and what hemodynamic parameters play important roles in aneurysm formation have not been quantified and assessed. Methods and Results: Thirty patients were included and based one computed tomography angiography, they were divided into three groups (10 patients per group): a normal group (normal CoW… More >

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