TING LAN, SHENG QIN, XIAOJIN GONG, PING ZHENG, JIAXIN YAN, YANG LIU*
BIOCELL, Vol.45, No.5, pp. 1313-1319, 2021, DOI:10.32604/biocell.2021.015923
Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk
human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the
stratified mucin-producing intraepithelial lesion (SMILE). ISMC can display variable architectural patterns and usually
coexists with other more conventional types of HPV-associated carcinomas, which makes diagnosis and differential
diagnosis of ISMC is difficult for pathologists. Moreover, the prognosis of ISMC is still controversial. We analyzed 6
ISMCs with detailed pathological and clinical information. Intraepithelial lesion, including 1 high-grade squamous
intraepithelial lesion and 1 SMILE, was found. Various architectures were observed (including nest, glandular, solid,
trabecular, and… More >
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