ROGHAYEH GHORBANI¹, MAHMOUD GHARBAVI², ALI SHARAFI^3,4, ELHAM RISMANI⁵, HAMED REZAEEJAM⁶, YOUSEF MORTAZAVI^1,*, BEHROOZ JOHARI^3,*

Oncology Research, Vol.32, No.1, pp. 101-125, 2024, DOI:10.32604/or.2023.044741

Abstract In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics assays. ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure. The physicochemical characteristics of nanostructures were determined by FTIR, DLS, UV-vis, TEM, EDX, in vitro release, and hemolysis tests. Subsequently, the cytotoxicity properties of them with and without X-irradiation were investigated by uptake, MTT, cell cycle, apoptosis, and scratch assays on… More > Graphic Abstract

Mohanad A. Mohammed^*, Hala B. Abdul Wahab

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1731-1748, 2024, DOI:10.32604/cmes.2023.030528

Abstract Blockchain technology has garnered significant attention from global organizations and researchers due to its potential as a solution for centralized system challenges. Concurrently, the Internet of Things (IoT) has revolutionized the Fourth Industrial Revolution by enabling interconnected devices to offer innovative services, ultimately enhancing human lives. This paper presents a new approach utilizing lightweight blockchain technology, effectively reducing the computational burden typically associated with conventional blockchain systems. By integrating this lightweight blockchain with IoT systems, substantial reductions in implementation time and computational complexity can be achieved. Moreover, the paper proposes the utilization of the Okamoto Uchiyama encryption algorithm, renowned for… More >

MENGYING MAO^1,2,3,#, TING DONG^1,2,3,#, YANJING LIANG^3,4, KEYONG YUAN^1,2,3, QIAOQIAO JIN^1,2,3, PENGFEI ZHANG^1,2,3, ZHENGWEI HUANG^1,2,3,*

BIOCELL, Vol.47, No.10, pp. 2187-2193, 2023, DOI:10.32604/biocell.2023.042357

Abstract The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and is highly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balance existing between the oral microbiota and host may be disturbed and result in the development of diseases. Numerous observations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host interactions. Further, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacious therapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria… More > Graphic Abstract

VIBHAV VARSHNEY^1,*, PRASHANT SINGH KUSHWAH², NEETU AGRAWAL¹, AHSAS GOYAL^1,*, GOVIND SINGH²

BIOCELL, Vol.47, No.10, pp. 2141-2149, 2023, DOI:10.32604/biocell.2023.030853

Abstract The persistent global pandemic, COVID-19, stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yielding an unprecedented worldwide crisis. With reference to a WHO report, the count of COVID-19 cases had exceeded 754 million by February 03, 2023. Intriguingly, emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities, acting as potent immunomodulatory factors at the cellular and molecular levels. This interconnection operates through a series of dynamic mechanisms. SARS-CoV-2 infection perturbs the delicate equilibrium of gut microbiota, leading to dysbiosis—a signature biomarker. This imbalance is intrinsically linked to exacerbated COVID-19 progression. Mechanistically,… More >

PAVITHRA SUBRAMANI^1,2, RAUNAK KUMAR DAS^1,*

BIOCELL, Vol.47, No.10, pp. 2195-2205, 2023, DOI:10.32604/biocell.2023.030383

Abstract Solar ultraviolet B (UVB) radiation is a major skin cancer-causing agent. Initiation, promotion, and progression are the diverse phases of UVB-induced carcinogenesis. Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways: thymine dimer formation, DNA damage, oxidative stress, inflammatory responses, and altered cell signaling, eventually resulting in tumor formation. The increased skin cancer rates urge researchers to develop more efficient drugs, but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues, which have been reported recently. The current review focuses on the relationship between microbes and cancer. Human skin acts as a barrier against… More > Graphic Abstract

Dana F. Doghramachi^1,*, Siddeeq Y. Ameen²

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 717-732, 2023, DOI:10.32604/cmc.2023.041186

Abstract The rapid adoption of the Internet of Things (IoT) across industries has revolutionized daily life by providing essential services and leisure activities. However, the inadequate software protection in IoT devices exposes them to cyberattacks with severe consequences. Intrusion Detection Systems (IDS) are vital in mitigating these risks by detecting abnormal network behavior and monitoring safe network traffic. The security research community has shown particular interest in leveraging Machine Learning (ML) approaches to develop practical IDS applications for general cyber networks and IoT environments. However, most available datasets related to Industrial IoT suffer from imbalanced class distributions. This study proposes a… More >

Fadhil Mukhlif^1,*, Norafida Ithnin¹, Roobaea Alroobaea², Sultan Algarni³, Wael Y. Alghamdi², Ibrahim Hashem⁴

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 583-599, 2023, DOI:10.32604/cmc.2023.038757

Abstract The World Health Organization (WHO) refers to the 2019 new coronavirus epidemic as COVID-19, and it has caused an unprecedented global crisis for several nations. Nearly every country around the globe is now very concerned about the effects of the COVID-19 outbreaks, which were previously only experienced by Chinese residents. Most of these nations are now under a partial or complete state of lockdown due to the lack of resources needed to combat the COVID-19 epidemic and the concern about overstretched healthcare systems. Every time the pandemic surprises them by providing new values for various parameters, all the connected research… More >

Yu-Rim Lee¹, Na-Eun Park¹, Seo-Yi Kim², Il-Gu Lee^1,2,*

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3465-3482, 2023, DOI:10.32604/cmc.2023.041196

Abstract With the introduction of 5G technology, the application of Internet of Things (IoT) devices is expanding to various industrial fields. However, introducing a robust, lightweight, low-cost, and low-power security solution to the IoT environment is challenging. Therefore, this study proposes two methods using a data compression technique to detect malicious traffic efficiently and accurately for a secure IoT environment. The first method, compressed sensing and learning (CSL), compresses an event log in a bitmap format to quickly detect attacks. Then, the attack log is detected using a machine-learning classification model. The second method, precise re-learning after CSL (Ra-CSL), comprises a… More >

Vijey Thayananthan¹, Aiiad Albeshri², Hassan A. Alamri³, Muhammad Bilal Qureshi⁴, Muhammad Shuaib Qureshi^5,*

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 2573-2595, 2023, DOI:10.32604/cmc.2023.040184

Abstract Complex networks on the Internet of Things (IoT) and brain communication are the main focus of this paper. The benefits of complex networks may be applicable in the future research directions of 6G, photonic, IoT, brain, etc., communication technologies. Heavy data traffic, huge capacity, minimal level of dynamic latency, etc. are some of the future requirements in 5G+ and 6G communication systems. In emerging communication, technologies such as 5G+/6G-based photonic sensor communication and complex networks play an important role in improving future requirements of IoT and brain communication. In this paper, the state of the complex system considered as a… More >

Naveed Khan¹, Jianbiao Zhang^1,*, Ghulam Ali Mallah², Shehzad Ashraf Chaudhry³

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3877-3896, 2023, DOI:10.32604/cmc.2023.032553

Abstract The mobile cellular network provides internet connectivity for heterogeneous Internet of Things (IoT) devices. The cellular network consists of several towers installed at appropriate locations within a smart city. These cellular towers can be utilized for various tasks, such as e-healthcare systems, smart city surveillance, traffic monitoring, infrastructure surveillance, or sidewalk checking. Security is a primary concern in data broadcasting, particularly authentication, because the strength of a cellular network’s signal is much higher frequency than the associated one, and their frequencies can sometimes be aligned, posing a significant challenge. As a result, that requires attention, and without information authentication, such… More >