CHEN-LIANG TSAI1, YU-HUEI LIN2, CHIH-YING CHANGCHIEN3, CHIH-FENG CHIAN1,#,*, CHI-HUEI CHIANG4,#,*
BIOCELL, Vol.45, No.5, pp. 1201-1211, 2021, DOI:10.32604/biocell.2021.014279
Abstract Primary lung graft dysfunction could significantly attribute to ischemia-reperfusion lung injury (IRLI) during
transplantation surgery. β2-adrenergic agonists were one of the bronchodilators that had been well-established in the
management of asthma and chronic obstructive pulmonary disease (COPD) with anti-inflammatory potency. By
applying the model of isolated rat lung, we evaluated the efficacy of short-acting β2-agonist inhalation to ameliorate
ischemia-reperfusion damage. The experiment protocol was 180 min of global ischemia and then reperfusion for
60 min. In the β2-agonist inhalation group, aerosolized albuterol was administrated prior ischemia procedure.
Increased weight ratios of wet to dry lung and microvascular permeability were characterized… More >
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