XINGXING ZHU1,2, TIANFENG HUA1,2, MINGFEI WU3, JIATIAN WU1,2, JIANCHAO HONG1,2, MIN YANG1,2,*
BIOCELL, Vol.44, No.3, pp. 431-441, 2020, DOI:10.32604/biocell.2020.010323
Abstract Post-resuscitation myocardial dysfunction (PRMD) is the most severe myocardial ischemia-reperfusion injury
(MIRI) and is characterized by difficult treatment and poor prognosis. Research has shown the protective effects of the
rational use of ivabradine (IVA) against PRMD; however, the molecular mechanisms of IVA remain unknown. In this
study, an ischemia-reperfusion injury (IRI) model was established using hypoxic chambers. The results demonstrated
that pretreatment with IVA reduced IRI-induced cytotoxicity and apoptosis. IVA attenuated mitochondrial damage,
eliminated excess reactive oxygen species (ROS), suppressed IRI-induced ATP and NAD+
, and increased the
AMP/ATP ratio. We further found that IVA increased the mRNA levels of… More >
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