Xiaona Li1,*, Sijia Wang1, Jie Song1, Yixian Qin2, Jizhong Yang3, Rui He4,*, Weiyi Chen1
Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 11-19, 2021, DOI:10.32604/mcb.2021.014071
Abstract The cornea is a load-bearing tissue. Lower biomechanical properties in the local tissue of keratoconic cornea evoke mechanical stress increase. Inflammatory cytokines have been shown to be over-expressed in patients with keratoconus. However, how mechanical stimuli are involved in the production of inflammatory cytokines in keratoconus remains unclear. The objective of the study is to determine the role of mechanical stretch in the regulation of inflammatory cytokines and the underlying mechanisms in keratoconus. Human keratoconic fibroblasts (hKCFs) were subjected to 12% cyclic mechanical stretch at 0.1 Hz or in static conditions as controls. N-acetyl cysteine (NAC) and pyrrolidine dithiocarbamate and… More >
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