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    miR-202 Suppresses Hepatocellular Carcinoma Progression via Downregulating BCL2 Expression

    Donghai Zhuang1, Li Liang1, Hongzhan Zhang, Xianguang Feng

    Oncology Research, Vol.28, No.4, pp. 399-408, 2020, DOI:10.3727/096504020X15864296270581

    Abstract miRNAs play an important role in progression of hepatocellular carcinoma (HCC). In this work, we assessed the function of miR-202 in human HCC and identified BCL2 as its target. We found miR-202 expression was found significantly downregulated, while BCL2 expression was markedly upregulated in HCC tissues and cell lines (HepG2, Hep3B, and HCCLM3). Both miR-202 and BCL2 were closely correlated with major vascular invasion and advanced TNM stage as well as overall survival of HCC patients. Overexpression of miR-202 significantly inhibited cell proliferation, induced apoptosis and cell cycle arrest at the G0/G1 phase, and prevented More >

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