Dong Hwan Ho1,*, Minhyung Lee2,3, Daleum Nam1, Hyejung Kim1, Janghwan Kim2,3, Mi Kyoung Seo4,5, Sung Woo Park4,5, Ilhong Son1,6,*
BIOCELL, Vol.49, No.7, pp. 1225-1244, 2025, DOI:10.32604/biocell.2025.065486
- 25 July 2025
Abstract Background: Parkinson’s disease (PD) is a common neurodegenerative disease, characterized by symptoms like tremors, muscle rigidity, and slow movement. The main cause of these symptoms is the loss of dopamine-producing neurons in a brain area called the substantia nigra. Various genetic and environmental factors contribute to this neuronal loss. Once symptoms of PD begin, they worsen with age, which also impacts several critical cellular processes. Leucine-rich repeat kinase 2 (LRRK2) is a gene associated with PD. Certain mutations in LRRK2, such as G2019S, increase its activity, disrupting cellular mechanisms necessary for healthy neuron function, including… More >
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