YONGKANG SHI, JUN MA, KE CHEN, BIN CHEN*
Oncology Research, Vol.30, No.4, pp. 201-210, 2022, DOI:10.32604/or.2022.027584
Abstract 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for various cancers. However, the drug
resistance developed by tumor cells hinders the therapeutic effect. Konjac glucomannan (KGM) is indicated to
sensitize 5-FU-resistant hepatocellular carcinoma (HCC) cells to 5-FU. In our study, we found that KGM or 5-FU
treatment alone did not affect the malignant cell behaviors and endoplasmic reticulum (ER) stress of 5-FU-resistant
HCC cells or HepG2/5-FU and Bel-7402/5-FU cells, while cotreatment with KGM and 5-FU significantly facilitated
HCC cell apoptosis and ER stress and suppressed cell proliferation potential and migration abilities. Moreover, we
explored the underlying mechanism by which KGM… More >
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