Haiyan Zhang*†, Yanxia Lu‡, Surong Wang‡, Xiugui Sheng§, Shiqian Zhang*
Oncology Research, Vol.27, No.3, pp. 335-340, 2019, DOI:10.3727/096504018X15252202178408
Abstract Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in
cervical cancer (CC) are poorly understood. Also, the association between miR-152 and Krüppel-like factor 5
(KLF5) expression in CC remains unclear. In this study, analyzing the expression of miR-152 by quantitative
real-time PCR (qRT-PCR) revealed it was sharply reduced in CC tissues and cell lines. In addition, the negative correlation of miR-152 expression and KLF5 expression was observed. The dual-luciferase reporter assay
validated that KLF5 was a target of miR-152. In vitro… More >
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