HAIYANG CHEN1,2,#, JINGYAO SU1,#, DANYANG CHEN1,#, YUYE DU1, RUILIN ZHENG1, QINGLIN DENG2, QIANQIAN DU3, BING ZHU1,*, YINGHUA LI1,*
BIOCELL, Vol.46, No.10, pp. 2267-2273, 2022, DOI:10.32604/biocell.2022.020218
Abstract At present, Hepatocarcinoma is one of the main causes of tumor related death all over the world. However, there are still many clinical restrictions on the treatment of liver cancer. Recently, L-Selenocystine has been shown to be a novel treatment for tumors, especially human glioma cells. But, the mechanism of L-Selenocystine against hepatocellular carcinoma remains unclear. Therefore, the main objective of this study was to investigate the effects of L-Selenocystine on HepG2 cell proliferation and activation of reactive oxygen species (ROS) mediated signaling pathway. L-Selenocystine can significantly inhibit HepG2 cell proliferation by activating caspase-3 and cleaving PARP to induce apoptosis.… More >
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