M. Louise Morrison1, Corrina McMahon2, Riona Tully1, Noelle Enright1, Ricardo Pignatelli3, Jeffrey A. Towbin4, Colin J. McMahon1
Congenital Heart Disease, Vol.13, No.3, pp. 440-443, 2018, DOI:10.1111/chd.12592
Abstract Objectives: Incidence of sickle cell disease (SCD) in Ireland has dramatically increased. Disease
survival has also steadily improved however cardiovascular manifestations remain important causes
of morbidity. These include reports of left ventricular hypertrabeculation (LVHT)/noncompaction.
We sought to investigate the prevalence of LVHT among a large cohort of children with SCD.
Methods: We retrospectively reviewed the records of all patients with a diagnosis of SCD who had
undergone surveillance echocardiography at Our Lady’s Children’s Hospital Crumlin (OLCHC) from
1998 to 2015. Demographics, hemoglobin phenotype and treatment information was recorded. LV
systolic function, evidence of LVHT, and possible pulmonary arterial hypertension was… More >
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