DONGYUE ZHANG, LINA WANG, HAO WANG, XIAOQIAN LV, QIAN REN, GUOGUANG ZHENG*
BIOCELL, Vol.45, No.1, pp. 149-156, 2021, DOI:10.32604/biocell.2021.010334
Abstract Legumain is a C13 family cysteine protease. It plays diverse roles under both physiological and pathological
conditions. The high-level expression of legumain is detected in solid tumors. Legumain promotes the proliferation
and migration of tumor cells. However, the effect of legumain in blood diseases has not been established. In this
report, we studied the effect of legumain on leukemia cells by overexpressing it in THP1 cells. The results
demonstrated that legumain promoted cell proliferation, whereas it had little effect on cell apoptosis. Furthermore,
legumain promoted the migration of THP1 cells. It was worth noting that legumain decreased the stemness of… More >
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