FAZLUR RAHMAN1,#, SHAMS TABREZ1,#, RAHAT ALI1, SAJJADUL KADIR AKAND1, MOHAMMED A. ALAIDAROUS2,3, MOHAMMED ALSAWEED2, BADER MOHAMMED ALSHEHRI2, SAEED BANAWAS2,3, ABDUR RUB1,*, ABDUL AZIZ BIN DUKHYIL2,*
BIOCELL, Vol.45, No.6, pp. 1601-1610, 2021, DOI:10.32604/biocell.2021.016682
Abstract Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different
species of the genus Leishmania. It is transmitted by the bite of female phlebotomies sand fly. Three main clinical
manifestations of leishmaniasis include cutaneous, visceral, and mucocutaneous leishmaniasis. Visceral leishmaniasis
(VL) caused by Leishmania donovani, is an infection of reticuloendothelial system and fatal if untreated. Cholesterol,
a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent
in plants, yeast, and protozoa, respectively. Ergosterols which is absent in human being, is an important constituent of
parasite membrane. Sterol… More >
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