JUN-JIE YU, WAN-XI YANG^*

BIOCELL, Vol.49, No.1, pp. 93-107, 2025, DOI:10.32604/biocell.2024.058299 - 24 January 2025

Abstract Hedgehog (HH) signaling has been researched for decades and Hedgehog has 3 homologs: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). Dhh is the one involved in male gonad and germ cell development. The distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis development. The patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH signaling. Some results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with More > Graphic Abstract

YUAN BI^1,2,#, TIANQI LI^2,#, HONGJIE PAN², MING GUO², LIANGKANG CHEN², QI QI¹, MEIXIN ZHANG², LINGLING ZHANG², LININ YU², XIAOFENG WAN², HUAJUN ZHENG^2,*, RUNSHENG LI^2,*

BIOCELL, Vol.44, No.3, pp. 301-313, 2020, DOI:10.32604/biocell.2020.011208 - 22 September 2020

Abstract Elemental sulfur has been used as a traditional Chinese medicine to treat the late-onset hypogonadism and impotence without a clarified mechanism for many hundreds of years. In the present study, mice were received sulfur or distilled water for 35 days by daily intragastric gavage at a dose of 250 mg/kg body weight. Then, the serum testosterone level and genes associated with testicular testosterone biosynthesis (TTB) were detected. The gut microbiota was also analyzed by 16S rRNA gene sequencing. Serum testosterone level was significantly increased by 291.1% in sulfur-treated mice. The H₂S levels in serum and feces… More >

MARTA B. CASANOVA, LIVIA LUSTIG, EMILCE S. DIAZ, ELIANA H. PELLIZZARI*, SELVA B. CIGORRAGA*, BERTA DENDUCHIS

BIOCELL, Vol.30, No.3, pp. 431-438, 2006, DOI:10.32604/biocell.2006.30.431

Abstract Caveolin-1, the first member of caveolin family reported, is recognized as the structural component of caveola, a plasma membrane invagination or vesicles that are a subcompartment distinct from clathrin-coated pits. This protein is also known to be involved in cholesterol trafficking.
The aim of this study was to determine the expression of caveolin-1 in adult rat Leydig cells. Testis sections incubated with an antibody to caveolin-1 showed, by immunohistochemistry, a moderate number of Leydig cells with different degrees of immunoreaction and a strong reaction in endothelial cells and in the lamina propia of seminiferous tubules.… More >