ALICIA I. WEYERS, LAURA I. UGNIA, HUGO GARCÍA OVANDO, NORA B. GORLA*
BIOCELL, Vol.26, No.2, pp. 225-228, 2002, DOI:10.32604/biocell.2002.26.225
Abstract Ciprofloxacin (CFX) is an effective and relatively safe antimicrobial used in a variety of human infections. However, adverse drug reactions and positive results in genotoxic tests are reported.
In order to understand the possible pathophysiological mechanisms of the toxic effects informed for CFX, lipid hydroperoxides (LOOH) -oxidative mediators of peroxidation- were quantified in liver and kidney of mice, after 15 to 360 minutes of the ciprofloxacin administration at doses of 10 mg/ Kg or 100 mg/ Kg by ip route. The peroxidation in the lipid fraction was evaluated by measuring the amount of hydroperoxides through the oxidation of 1-… More >
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