ELYN AMIELA SALLEH¹, YEONG YEH LEE², ANDEE DZULKARNAEN ZAKARIA³, NUR ASYILLA CHE JALIL⁴, MARAHAINI MUSA^1,*

BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541

Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient… More > Graphic Abstract

Decheng Li¹, Yan Zhang², Dongdong Ma², Haozhe Geng¹, Yu Wu^1,2,*

Energy Engineering, Vol.120, No.11, pp. 2503-2516, 2023, DOI:10.32604/ee.2023.041803

Abstract The fracturing process of sandstone is inherently complex due to its loose internal structure and deformation adaptability. Liquid nitrogen pre-injection has emerged as a promising approach to damage reservoir rocks, effectively reducing fracture pressure and establishing intricate fracture networks, thus offering a potential solution for reservoir reconstruction. To unravel the fundamental mechanisms governing sandstone fracturing behaviors following liquid nitrogen pre-injection, sandstone fracturing experiments were conducted under varying durations of liquid nitrogen injection, rock temperature, and in-situ stress conditions. The experiments showcased the evolution of injection pressure and fracture characteristics under different testing conditions, complemented by electron microscope analysis to elucidate… More >

Shaopeng Liu¹, Guowei Wang^2,3,*, Pengfei Liu¹, Dong Ye¹, Jian Song¹, Xing Liu¹, Yang Cheng^2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.12, pp. 3045-3058, 2023, DOI:10.32604/fdmp.2023.029810

Abstract Foam drainage is the flow of liquid through the interstitial spaces between bubbles driven by capillarity and gravity and resisted by viscous damping. The so-called foam drainage gas recovery technology is a technique traditionally used to mitigate the serious bottom-hole liquid loading in the middle and late stages of gas well production. In this context, determining the optimal concentration of the bubble drainage agent is generally crucial for the proper application of this method. In this study, a combination of indoor experiments and theoretical analysis have been used to determine the pressure drop related to the foam-carrying capacity in a… More >

Yun Lei^1,2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.12, pp. 3021-3032, 2023, DOI:10.32604/fdmp.2023.029570

Abstract The highly inefficient simultaneous extraction of coal and gas from low-permeability and high-gas coal seams in deep mines is a major problem often restricting the sustainable development of coal industry. A possible way to solve this problem under deep and complex geological conditions is represented by the technology based on the phase-change induced explosion of liquid carbon dioxide. In this work, the mechanism of formation of the coal mass fracture circle resulting from the gas cracking process is theoretically analyzed. Numerical simulations show that a blasting crushing zone with a radius of 1.0 m is formed around the blasting hole.… More >

Linjuan Zeng¹, Daogang Cai¹, Yunhai Zhao^1,*, Changqing Ye¹, Chengcheng Luo²

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.11, pp. 2813-2825, 2023, DOI:10.32604/fdmp.2023.026190

Abstract The flow behavior of shale gas horizontal wells is relatively complex, and this should be regarded as the main reason for which conventional pipe flow models are not suitable to describe the related dynamics. In this study, numerical simulations have been conducted to determine the gas-liquid distribution in these wells. In particular, using the measured flow pressure data related to 97 groups of shale gas wells as a basis, 9 distinct pipe flow models have been assessed, and the models displaying a high calculation accuracy for different water-gas ratio (WGR) ranges have been identified. The results show that: (1) The… More >

Fengchao Wang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09711

Abstract Wetting and capillary phenomena on the macroscale are ubiquitous and have been well understood. However, the relevant physics and mechanics on the nano-scale still remain mysterious. In this talk, I would like to discuss the exploration of capillarity from a nanoscopic perspective, including wetting, evaporation and condensation. At the solid/liquid interface, the liquid exhibits a pronounced layered structure that extends over several intermolecular distances from the solid surface. Our recent studies have shown that such molecular detail could provide some new understanding on century-old classical theory in this field, such as Young’s equation [1] and Kelvin equation [2]. More >

Pengcheng Nie^1,2, Xikai Jiang¹, Xu Zheng¹, Dongshi Guan^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09838

Abstract “How can we measure interface phenomena on the microscopic level” is a fundamental question that has been with us for many years and is also listed in recent Science 125 question. It is even harder to explore the electrified interface. In this work, we report atomic-force-microscope measurements of interfacial dynamics of an electrified room-temperature ionic liquid (RTIL)-solid interface. RTILs are intriguing fluids that have drawn much attention in applications ranging from tribology and catalysis to energy storage. With strong electrostatic interaction between ions, their interfacial behaviors can be modulated by controlling energetics of the electrified interface. Using a unique long-needle… More >

EFFAT ALEMZADEH¹, LEILA ALLAHQOLI², HAMIDEH DEHGHAN³, AFROOZ MAZIDIMORADI⁴, ALIREZA GHASEMPOUR³, HAMID SALEHINIYA^5,*

Oncology Research, Vol.31, No.5, pp. 667-675, 2023, DOI:10.32604/or.2023.028406

Abstract Liquid biopsy, including both circulating tumor cells and circulating tumor DNA, is becoming more popular as a diagnostic tool in the clinical management of breast cancer. Elevated concentrations of these biomarkers during cancer treatment may be used as markers for cancer progression as well as to understand the mechanisms underlying metastasis and treatment resistance. Thus, these circulating markers serve as tools for cancer assessing and monitoring through a simple, non-invasive blood draw. However, despite several study results currently noting a potential clinical impact of ctDNA mutation tracking, the method is not used clinically in cancer diagnosis among patients and more… More > Graphic Abstract

Fakher Oueslati^a,b,†, Brahim Ben-Beya^b

Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-11, 2017, DOI:10.5098/hmt.8.38

Abstract The current study deals with a numerical investigation of magnetoconvection and entropy generation within a lid driven square cavity subject to uniform magnetic field and filled with liquid metal. Effects of multiple parameters namely; the Prandtl, Hartmann and Richardson numbers were predicted and analyzed using a numerical methodology based on the finite volume method and a full multigrid technique. The numerical outcome of the present study shows that, the enhancement of Hartmann number declines the heat transfer rate for all liquid metals considered. Moreover, it is observed that augmenting the Richardson number leads to acceleration of the flow with a… More >

Vijayakumar Thulasi, R. Thundil Karuppa Raj^*

Frontiers in Heat and Mass Transfer, Vol.10, pp. 1-9, 2018, DOI:10.5098/hmt.10.33

Abstract Diethyl ether is one of the potential alternative fuels for the high speed compression ignition engines that can replace the existing neat diesel fuel. It is well known that the combustion characteristic of a compression ignition engine is highly influenced by the fuel spray structure formed during the injection process. In this paper the spray structure formation for the diethyl ether fuel is studied numerically, using the discrete phase model and it is compared with the neat diesel fuel. The spray is investigated in a constant volume chamber maintained at 30 bar pressure. The fuel is injected into the chamber… More >