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  • Open Access

    PROCEEDINGS

    Dynamic Compression and Energy Absorption Behaviours of a Nanofluidic Liquid Foam

    Haiqi Feng1, Wei Huang1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-2, 2023, DOI:10.32604/icces.2023.09347

    Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio [1-7]. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static… More >

  • Open Access

    ARTICLE

    Numerical Investigations on Effects of Physical Parameters on Single Bubble Generation from Capillary Needles in Newtonian Liquids

    Meng Jia, Mingjun Pang*

    Frontiers in Heat and Mass Transfer, Vol.21, pp. 337-366, 2023, DOI:10.32604/fhmt.2023.044286

    Abstract The interphase mass, heat transfer efficiency, and flow resistance are strongly dependent on bubble size in gasliquid two-phase systems, so it is very important for engineering applications to effectively control bubble size. In this paper, the formation, growth, and detachment of single bubbles in Newtonian liquids based on capillary needles were studied in detail using a volume of fluid method. The authors investigated the effects of gas injection velocity, gravitational level, surface tension coefficient, needle radius, and liquid−phase properties (liquid viscosity and density) on the process of bubble generation, and the effects of the above… More >

  • Open Access

    REVIEW

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

    ELYN AMIELA SALLEH1, YEONG YEH LEE2, ANDEE DZULKARNAEN ZAKARIA3, NUR ASYILLA CHE JALIL4, MARAHAINI MUSA1,*

    BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541

    Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed… More > Graphic Abstract

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

  • Open Access

    ARTICLE

    Experimental Investigation on Fracturing Behaviors after Liquid Nitrogen Pre-Injection in High-Temperature Sandstone

    Decheng Li1, Yan Zhang2, Dongdong Ma2, Haozhe Geng1, Yu Wu1,2,*

    Energy Engineering, Vol.120, No.11, pp. 2503-2516, 2023, DOI:10.32604/ee.2023.041803

    Abstract The fracturing process of sandstone is inherently complex due to its loose internal structure and deformation adaptability. Liquid nitrogen pre-injection has emerged as a promising approach to damage reservoir rocks, effectively reducing fracture pressure and establishing intricate fracture networks, thus offering a potential solution for reservoir reconstruction. To unravel the fundamental mechanisms governing sandstone fracturing behaviors following liquid nitrogen pre-injection, sandstone fracturing experiments were conducted under varying durations of liquid nitrogen injection, rock temperature, and in-situ stress conditions. The experiments showcased the evolution of injection pressure and fracture characteristics under different testing conditions, complemented by… More >

  • Open Access

    ARTICLE

    Optimal Concentration of the Bubble Drainage Agent in Foam Drainage Gas Recovery Applications

    Shaopeng Liu1, Guowei Wang2,3,*, Pengfei Liu1, Dong Ye1, Jian Song1, Xing Liu1, Yang Cheng2,3

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.12, pp. 3045-3058, 2023, DOI:10.32604/fdmp.2023.029810

    Abstract Foam drainage is the flow of liquid through the interstitial spaces between bubbles driven by capillarity and gravity and resisted by viscous damping. The so-called foam drainage gas recovery technology is a technique traditionally used to mitigate the serious bottom-hole liquid loading in the middle and late stages of gas well production. In this context, determining the optimal concentration of the bubble drainage agent is generally crucial for the proper application of this method. In this study, a combination of indoor experiments and theoretical analysis have been used to determine the pressure drop related to… More >

  • Open Access

    ARTICLE

    Numerical-Experimental Analysis of the Coal Fracture Formation Mechanism Induced by Liquid CO2 Explosion

    Yun Lei1,2,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.12, pp. 3021-3032, 2023, DOI:10.32604/fdmp.2023.029570

    Abstract The highly inefficient simultaneous extraction of coal and gas from low-permeability and high-gas coal seams in deep mines is a major problem often restricting the sustainable development of coal industry. A possible way to solve this problem under deep and complex geological conditions is represented by the technology based on the phase-change induced explosion of liquid carbon dioxide. In this work, the mechanism of formation of the coal mass fracture circle resulting from the gas cracking process is theoretically analyzed. Numerical simulations show that a blasting crushing zone with a radius of 1.0 m is More >

  • Open Access

    ARTICLE

    Analysis of Wellbore Flow in Shale Gas Horizontal Wells

    Linjuan Zeng1, Daogang Cai1, Yunhai Zhao1,*, Changqing Ye1, Chengcheng Luo2

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.11, pp. 2813-2825, 2023, DOI:10.32604/fdmp.2023.026190

    Abstract The flow behavior of shale gas horizontal wells is relatively complex, and this should be regarded as the main reason for which conventional pipe flow models are not suitable to describe the related dynamics. In this study, numerical simulations have been conducted to determine the gas-liquid distribution in these wells. In particular, using the measured flow pressure data related to 97 groups of shale gas wells as a basis, 9 distinct pipe flow models have been assessed, and the models displaying a high calculation accuracy for different water-gas ratio (WGR) ranges have been identified. The More >

  • Open Access

    PROCEEDINGS

    Wetting and Capillary Condensation on the Nanoscale

    Fengchao Wang1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09711

    Abstract Wetting and capillary phenomena on the macroscale are ubiquitous and have been well understood. However, the relevant physics and mechanics on the nano-scale still remain mysterious. In this talk, I would like to discuss the exploration of capillarity from a nanoscopic perspective, including wetting, evaporation and condensation. At the solid/liquid interface, the liquid exhibits a pronounced layered structure that extends over several intermolecular distances from the solid surface. Our recent studies have shown that such molecular detail could provide some new understanding on century-old classical theory in this field, such as Young’s equation [1] and More >

  • Open Access

    PROCEEDINGS

    Probing Electrified Ionic Liquid-Solid Interface Using Long-Needle AFM

    Pengcheng Nie1,2, Xikai Jiang1, Xu Zheng1, Dongshi Guan1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09838

    Abstract “How can we measure interface phenomena on the microscopic level” is a fundamental question that has been with us for many years and is also listed in recent Science 125 question. It is even harder to explore the electrified interface. In this work, we report atomic-force-microscope measurements of interfacial dynamics of an electrified room-temperature ionic liquid (RTIL)-solid interface. RTILs are intriguing fluids that have drawn much attention in applications ranging from tribology and catalysis to energy storage. With strong electrostatic interaction between ions, their interfacial behaviors can be modulated by controlling energetics of the electrified… More >

  • Open Access

    REVIEW

    Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoring

    EFFAT ALEMZADEH1, LEILA ALLAHQOLI2, HAMIDEH DEHGHAN3, AFROOZ MAZIDIMORADI4, ALIREZA GHASEMPOUR3, HAMID SALEHINIYA5,*

    Oncology Research, Vol.31, No.5, pp. 667-675, 2023, DOI:10.32604/or.2023.028406

    Abstract Liquid biopsy, including both circulating tumor cells and circulating tumor DNA, is becoming more popular as a diagnostic tool in the clinical management of breast cancer. Elevated concentrations of these biomarkers during cancer treatment may be used as markers for cancer progression as well as to understand the mechanisms underlying metastasis and treatment resistance. Thus, these circulating markers serve as tools for cancer assessing and monitoring through a simple, non-invasive blood draw. However, despite several study results currently noting a potential clinical impact of ctDNA mutation tracking, the method is not used clinically in cancer More > Graphic Abstract

    Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoring

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