Xiaojian You¹, Zhen Sun¹, Lei Zhang¹, Weikun Qian¹, Cong Wang¹, Weigang Pang¹, Hongming Li¹, Yingshuang Cui¹, Chen Chen¹, Yue Wang¹, Xiao Wu^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.081350 - 27 May 2026

Abstract Slug flow poses significant dynamic challenges in multiphase pipeline transport, particularly in complex offshore and Floating Liquefied Natural Gas systems, where conventional one- and two-dimensional models fail to capture the intricate three-dimensional interfacial topologies and transient liquid-film dynamics. To overcome this limitation, the present study develops a three-dimensional transient numerical model based on the coupled level-set and volume-of-fluid (CLSVOF) method within a large eddy simulation (LES) framework, and validates it against high-frequency measurements obtained from a double parallel conductance probe experimental platform. The proposed model successfully resolves phase velocity slip and interfacial morphological evolution, predicting More >

Hui Sun^1,2, Jianwei Zhang^1,2, Wenbo Shi^1,2, Zhenhao Liu^1,2, Jianxin Xu^1,2,*, Hua Wang^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.080128 - 27 May 2026

Abstract Uniformity in solid-liquid mixing is a critical aspect for mass and heat transfer efficiency in multiphase reactors. This highlights the necessity for rigorous quantitative approaches capable of resolving spatial heterogeneity across multiple scales. In this work, a coupled discrete element method-volume of fluid (DEM-VOF) framework is employed to simulate the suspension dynamics of 20,000 particles, each 2 mm in diameter, within a liquid medium. To achieve a quantitative and multiscale characterization of three-dimensional particle distributions, Ripley’s L function, rooted in spatial statistics, is introduced and systematically applied. Its validity and robustness are further corroborated through… More >

Penghui Zhang^1,2, Nan Lin^2,*, Yang Wang^1,*, Ming Sun², Sixi Zha¹, Zongjie Zhou¹, Chenglin Li³

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.078553 - 27 May 2026

Abstract Erosion-corrosion in refining and chemical plant pipelines remains a persistent integrity concern, particularly in straight sections located downstream of elbows, which are rarely prioritized in inspection programs that typically focus on elbows and tees despite their well-known vulnerability. In these downstream regions, developing flow structures can sustain wall impingement and liquid film formation, leading to progressive material loss that is often underestimated in practice. This work examines a representative industrial pipeline through a combined approach based on computational fluid dynamics (CFD) simulations and controlled experimental validation to resolve the hydrodynamic behavior in the straight pipe… More >

Maher Kurdi^1,*, Amber Hassan², Bashar Reda³, Anas Nooh³, Mohammed Alsobaie⁴, Alaa Alkhotani⁵, Dahlia S. Mirdad⁶, Majid Almansouri⁷, Khalid Khashoggi⁸, Manal Halwani⁹, Motaz Fadul¹, Humaira Waseem^10,11, Siti S. Maidin¹⁰, Muhammed Imtiaz Farid¹²

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078833 - 21 May 2026

Abstract Background: Pediatric sarcomas are aggressive malignancies characterized by marked biological heterogeneity and a high risk of relapse. Standard surveillance relies on imaging and invasive biopsies, which may fail to detect early molecular disease. Liquid biopsy using circulating tumor DNA (ctDNA) and microRNAs offers a minimally invasive strategy for longitudinal monitoring. This study aimed to evaluate dynamic changes in ctDNA and circulating microRNAs during treatment and examined their associations with treatment response, disease recurrence, and survival outcomes. Methods: This prospective cohort study included 100 pediatric patients with histologically confirmed sarcomas. Serial peripheral blood samples were collected at… More >

Yiyang Zhao¹, Changchang Sun¹, Qihan Dong², Jiangyang He¹, Yan Wang^1,3,*, Ling Bi^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.076499 - 21 May 2026

Abstract Liquid-liquid phase separation (LLPS) is an emerging biophysical principle that governs subcellular organization through the formation of dynamic, membraneless biomolecular condensates. This review aims to elucidate the multifaceted mechanisms by which dysregulated LLPS drives cancer drug resistance and to explore therapeutic strategies targeting oncogenic biomolecular condensates for improved anticancer outcomes. We synthesize evidence demonstrating that dysregulated LLPS drives cancer drug resistance through diverse mechanisms, including sustaining oncogenic transcription despite targeted therapies, creating physical barriers against chemotherapeutics, modulating immune checkpoint activity, enhancing DNA damage repair, promoting cancer stemness and radioresistance. By integrating insights from cell cycle More >

Thanh Hoa Vo^1,2, Edel McNeela^1,2, Orla O’Donnovan^1,2, Jai Prakash Mehta³, Van Hoa Nguyen⁴, Sweta Rani^1,2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.075346 - 21 May 2026

Abstract Long non-coding RNAs (lncRNAs) have emerged as key regulators of drug resistance in human epidermal growth factor receptor 2 (HER2)-positive breast cancer, a subtype in which both intrinsic and acquired resistance to HER2-targeted therapies remain major clinical challenges. Although mechanistic studies have begun to reveal how lncRNAs modulate signaling pathways, interact with microRNAs, and influence the tumor microenvironment, dedicated investigations in HER2-positive disease are still limited. This review synthesizes current evidence across epigenetic, transcriptional, and post-transcriptional mechanisms of resistance, including competing endogenous RNA (ceRNA) networks, RNA-binding protein interactions, and exosome-mediated intercellular communication. Particular emphasis is… More >

Jian Li^1,2,*, Kexiang Wen¹, Jian Wei¹, Dengke Wen¹, Ruihao Sun¹

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.4, 2026, DOI:10.32604/fdmp.2026.078680 - 07 May 2026

Abstract The effective management of gas–liquid two-phase flow, emerging within the microchannels of proton exchange membrane fuel cells (PEMFCs) during operations, is crucial for improving energy conversion efficiency. In this study, the influence of surface wettability is examined for hydrophilic and hydrophobic conditions through a visualization-based experimental setup focused on single-droplet dynamics. The impact of key parameters on droplet behavior is systematically explored, while the mechanisms underlying the observed flow patterns are elucidated and the coupling among governing physical factors is clarified. The results show that, under comparable conditions, hydrophobic surfaces exhibit larger advancing contact angles More >

Jialun Liu^1,2,3,*, Yuchang Lu⁴, Jianjun Lin³, Shebing Li³, Ruixia Gao⁵, Zhao Li⁶

Frontiers in Heat and Mass Transfer, Vol.24, No.2, 2026, DOI:10.32604/fhmt.2026.076292 - 30 April 2026

Abstract A steady thermo-hydraulic model of the helical tube steam generator was first constructed to study the coupled heat transfer process between the primary and secondary sides based on a discrete modeling method, and obtain the heat flux density distribution along the steam generator. Then, taking the obtained coupled heat flux density distribution as the thermal boundary condition input, considering the dynamic variation of physical properties on the secondary side, a dynamic model based on the time-domain method suitable for two-phase flow instability among parallel multiple channels of the steam generator was constructed. Finally, taking the… More >

Artem N. Kotov^*, Aleksandr A. Starostin, Aleksandr L. Gurashkin

Frontiers in Heat and Mass Transfer, Vol.24, No.2, 2026, DOI:10.32604/fhmt.2026.074926 - 30 April 2026

Abstract Dynamic methods for creating a superheated state of liquids and tracking their decay are presented. These methods allow relaxation characteristics of short-lived metastable states to be investigated across a wide range of temperatures and pressures. The relaxation of a medium is studied by a “probe” action after a short “pump” pulse. The concentration of the pump pulse in time and space allows the synchronization and localization of means for recording fast-flowing processes. Our aim was to carry out a brief review of methods for studying pulsed thermal processes in a superheated liquid based on the… More >

Omar Badran^1,2,*, Siraj Attarya³

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075916 - 22 April 2026

Abstract Extrachromosomal DNA (ecDNA) constitutes a principal factor in the amplification of oncogenes and the progression of tumors in solid malignancies. This review synthesizes emerging mechanistic, genomic, and immunologic evidence across multiple tumor types, including glioblastoma, lung, breast, gastrointestinal, hepatobiliary, urothelial, prostate, gynecologic, pediatric, and head-and-neck cancers, with the goal of clarifying the role of ecDNA in immune escape and therapy resistance and outlining its translational implications for precision oncology. ecDNA comprises substantial acentromeric circular elements that serve as transcriptional hubs, modulate enhancer–promoter interactions, and undergo dynamic copy-number cycling, thereby fostering intratumoral heterogeneity and resistance to… More >