Giuseppina Persico^#,*, Francesco Marciano^#, Sergio Cassese, Stefano Mungiguerra, Raffaele Savino

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.6, 2026, DOI:10.32604/fdmp.2026.081838 - 30 June 2026

Abstract Bipropellant rocket engines remain central to space exploration and the advancement of propulsion technology, offering the high performance and operational flexibility required for both launch vehicles and in-space applications. The growing shift toward sustainable, environmentally friendly propellants has intensified research into the precise modeling and understanding of combustion processes. In this scenario, small-scale rocket engines have proven to be indispensable research tools, providing cost-effective and adaptable platforms to investigate complex combustion phenomena and injector configurations while maintaining the fundamental physical characteristics of full-scale systems. Within this scope, a modular 200N-class bipropellant rocket engine platform, utilizing… More >

Yechao Qin¹, Zezhong Hou¹, Xiaojun Dai², Zhenqian Chen¹, Bo Xu^1,*

Frontiers in Heat and Mass Transfer, Vol.24, No.3, 2026, DOI:10.32604/fhmt.2026.079464 - 29 June 2026

Abstract To address the increasing thermal management demands of electronic devices, this study proposes a single-inlet, single-outlet counterflow double-layer microchannel structure optimized for non-uniform heat sources and conducts a numerical analysis. The research focuses on designing a double-layer microchannel structure through topology optimization under 2.5D chip non-uniform heat source conditions. Its heat dissipation performance is compared with traditional linear microchannels to analyze the advantages of the topology-optimized microchannel. In a simulated 2.5D heat source scenario comprising a 240 W logic chip and four 40 W memory chips, the average temperature at the bottom of the topologically… More >

Raquel Sanchez-Baltasar¹, Nerea Castañeda-Fernández¹, Jorge Olivares-Arancibia², Carlos Torres-Villar^3,4, Julio Plaza-Diaz^5,6,7,8,*, Lourdes Herrera-Quintana^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081924 - 16 June 2026

Abstract Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with substantial international disparities in incidence, stage at diagnosis, access to treatment, and survival. In recent years, BC management has evolved rapidly through advances in molecular characterization, imaging, pathology, targeted therapies, immunotherapy, and survivorship care. Nevertheless, important gaps persist in early and accurate detection, biomarker standardization, equitable access to care, and patient-specific treatment selection. These advances require timely, evidence-based, and context-specific clinical frameworks to support appropriate implementation, and to avoid the use of… More >

Xiaojian You¹, Zhen Sun¹, Lei Zhang¹, Weikun Qian¹, Cong Wang¹, Weigang Pang¹, Hongming Li¹, Yingshuang Cui¹, Chen Chen¹, Yue Wang¹, Xiao Wu^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.081350 - 27 May 2026

Abstract Slug flow poses significant dynamic challenges in multiphase pipeline transport, particularly in complex offshore and Floating Liquefied Natural Gas systems, where conventional one- and two-dimensional models fail to capture the intricate three-dimensional interfacial topologies and transient liquid-film dynamics. To overcome this limitation, the present study develops a three-dimensional transient numerical model based on the coupled level-set and volume-of-fluid (CLSVOF) method within a large eddy simulation (LES) framework, and validates it against high-frequency measurements obtained from a double parallel conductance probe experimental platform. The proposed model successfully resolves phase velocity slip and interfacial morphological evolution, predicting More >

Hui Sun^1,2, Jianwei Zhang^1,2, Wenbo Shi^1,2, Zhenhao Liu^1,2, Jianxin Xu^1,2,*, Hua Wang^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.080128 - 27 May 2026

Abstract Uniformity in solid-liquid mixing is a critical aspect for mass and heat transfer efficiency in multiphase reactors. This highlights the necessity for rigorous quantitative approaches capable of resolving spatial heterogeneity across multiple scales. In this work, a coupled discrete element method-volume of fluid (DEM-VOF) framework is employed to simulate the suspension dynamics of 20,000 particles, each 2 mm in diameter, within a liquid medium. To achieve a quantitative and multiscale characterization of three-dimensional particle distributions, Ripley’s L function, rooted in spatial statistics, is introduced and systematically applied. Its validity and robustness are further corroborated through… More >

Penghui Zhang^1,2, Nan Lin^2,*, Yang Wang^1,*, Ming Sun², Sixi Zha¹, Zongjie Zhou¹, Chenglin Li³

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.5, 2026, DOI:10.32604/fdmp.2026.078553 - 27 May 2026

Abstract Erosion-corrosion in refining and chemical plant pipelines remains a persistent integrity concern, particularly in straight sections located downstream of elbows, which are rarely prioritized in inspection programs that typically focus on elbows and tees despite their well-known vulnerability. In these downstream regions, developing flow structures can sustain wall impingement and liquid film formation, leading to progressive material loss that is often underestimated in practice. This work examines a representative industrial pipeline through a combined approach based on computational fluid dynamics (CFD) simulations and controlled experimental validation to resolve the hydrodynamic behavior in the straight pipe… More >

Maher Kurdi^1,*, Amber Hassan², Bashar Reda³, Anas Nooh³, Mohammed Alsobaie⁴, Alaa Alkhotani⁵, Dahlia S. Mirdad⁶, Majid Almansouri⁷, Khalid Khashoggi⁸, Manal Halwani⁹, Motaz Fadul¹, Humaira Waseem^10,11, Siti S. Maidin¹⁰, Muhammed Imtiaz Farid¹²

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078833 - 21 May 2026

Abstract Background: Pediatric sarcomas are aggressive malignancies characterized by marked biological heterogeneity and a high risk of relapse. Standard surveillance relies on imaging and invasive biopsies, which may fail to detect early molecular disease. Liquid biopsy using circulating tumor DNA (ctDNA) and microRNAs offers a minimally invasive strategy for longitudinal monitoring. This study aimed to evaluate dynamic changes in ctDNA and circulating microRNAs during treatment and examined their associations with treatment response, disease recurrence, and survival outcomes. Methods: This prospective cohort study included 100 pediatric patients with histologically confirmed sarcomas. Serial peripheral blood samples were collected at… More >

Yiyang Zhao¹, Changchang Sun¹, Qihan Dong², Jiangyang He¹, Yan Wang^1,3,*, Ling Bi^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.076499 - 21 May 2026

Abstract Liquid-liquid phase separation (LLPS) is an emerging biophysical principle that governs subcellular organization through the formation of dynamic, membraneless biomolecular condensates. This review aims to elucidate the multifaceted mechanisms by which dysregulated LLPS drives cancer drug resistance and to explore therapeutic strategies targeting oncogenic biomolecular condensates for improved anticancer outcomes. We synthesize evidence demonstrating that dysregulated LLPS drives cancer drug resistance through diverse mechanisms, including sustaining oncogenic transcription despite targeted therapies, creating physical barriers against chemotherapeutics, modulating immune checkpoint activity, enhancing DNA damage repair, promoting cancer stemness and radioresistance. By integrating insights from cell cycle More >

Thanh Hoa Vo^1,2, Edel McNeela^1,2, Orla O’Donnovan^1,2, Jai Prakash Mehta³, Van Hoa Nguyen⁴, Sweta Rani^1,2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.075346 - 21 May 2026

Abstract Long non-coding RNAs (lncRNAs) have emerged as key regulators of drug resistance in human epidermal growth factor receptor 2 (HER2)-positive breast cancer, a subtype in which both intrinsic and acquired resistance to HER2-targeted therapies remain major clinical challenges. Although mechanistic studies have begun to reveal how lncRNAs modulate signaling pathways, interact with microRNAs, and influence the tumor microenvironment, dedicated investigations in HER2-positive disease are still limited. This review synthesizes current evidence across epigenetic, transcriptional, and post-transcriptional mechanisms of resistance, including competing endogenous RNA (ceRNA) networks, RNA-binding protein interactions, and exosome-mediated intercellular communication. Particular emphasis is… More >

Jian Li^1,2,*, Kexiang Wen¹, Jian Wei¹, Dengke Wen¹, Ruihao Sun¹

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.4, 2026, DOI:10.32604/fdmp.2026.078680 - 07 May 2026

Abstract The effective management of gas–liquid two-phase flow, emerging within the microchannels of proton exchange membrane fuel cells (PEMFCs) during operations, is crucial for improving energy conversion efficiency. In this study, the influence of surface wettability is examined for hydrophilic and hydrophobic conditions through a visualization-based experimental setup focused on single-droplet dynamics. The impact of key parameters on droplet behavior is systematically explored, while the mechanisms underlying the observed flow patterns are elucidated and the coupling among governing physical factors is clarified. The results show that, under comparable conditions, hydrophobic surfaces exhibit larger advancing contact angles More >