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  • Open Access

    ARTICLE

    Effect of N,N-Dimethylacetamide/lithium chloride modified microcrystalline cellulose (MCC) on the processing behaviour and properties of celluloserubber (NBR and EPDM) composites

    LAVANYA, R1, NATCHIMUTHU, N2,*

    Journal of Polymer Materials, Vol.38, No.1-2, pp. 89-100, 2021, DOI:10.32381/JPM.2021.38.1-2.8

    Abstract Rubber composites of nitrile (NBR) and Ethylene-Propylene-Diene (EPDM) containing unmodified and modified microcrystalline cellulose(MCC) are evaluated for their processing behaviour. The used modified MCC (T-MCC) was treated by N,N-dimethylacetamide/lithium chloride (DMAc/ LiCl).ATR-FTIR spectra of NBR-MCC composites have indicated N-H stretching and bending vibrations and confirmed interactions between nitrile rubber and MCC. AFM studies have indicated that the average roughness of NBR-T-MCC was significantly reduced when compared to that of NBR-untreated MCC. Important processing parameters such as scorch time and cure time are found to decrease significantly for both NBR and EPDM composites withT-MCC. Mechanical properties of these composites are found… More >

  • Open Access

    ARTICLE

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

    CHONG SHEN, JIAJUN YAN*, YU REN, ZHIRONG ZHU, XIAOLONG ZHANG, SHUIXIANG TAO

    BIOCELL, Vol.48, No.1, pp. 97-109, 2024, DOI:10.32604/biocell.2023.045303

    Abstract Introduction: Bladder cancer (BC) has a high incidence and mortality rate worldwide. Suppressor anaphase-promoting complex domain containing 2 (SAPCDC2) is over-expressed in a variety of tumors. Objectives: This study investigated the effects of SAPCD2 knockdown on BC cells. Methods: T24 and UMUC3 cell models and the xenografted BC tumor model with SAPCD2 knockdown were established to observe the malignant phenotype of BC cells by cell counting kit-8 assay, colony formation test, wound healing, and Transwell assay, mRNA and proteins expressions were measured with quantitative real-time polymerase chain reaction, western blotting, and tissue immunohistochemistry. Lithium chloride agonist on the Wnt/β-catenin pathway… More > Graphic Abstract

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

  • Open Access

    ARTICLE

    Purmorphamine Promotes Matrix Mineralization and Cytoskeletal Changes in Human Umbilical Cord Mesenchymal Stem Cells

    Syed A Jamal*

    Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 267-273, 2013, DOI:10.3970/mcb.2013.010.267

    Abstract Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) were subjected to in vitro osteogenic differentiation using a novel combination of signaling molecules including BMP-2 and purmorphamine. Differentiation outcomes were assessed by calcein staining and by microscopic examination of the cytoskeleton. Calcein staining showed appreciable degree of calcium mineralization in cell culture, and changes in the morphological attributes of differentiating cells were observed vis-a-vis the actin cytoskeleton. Finally, positive calcein staining, altered cytoskeletal profile, and stress fiber formation in treated cells demonstrated, for the first time, a potentially synergistic interplay between BMP-2 and the hedgehog agonist, purmorphamine. This study lends support to… More >

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