TAO LIU1, LIMIN ZHOU1, LIANBO ZHANG2, XIN GUAN3, YI DONG1,*
Oncology Research, Vol.29, No.3, pp. 189-200, 2021, DOI:10.32604/or.2022.03573
Abstract Many studies have illustrated the significance of long noncoding RNAs in oncogenesis and promotion of breast
cancer (BC). However, the biological roles of CCDC183 antisense RNA 1 (CCDC183-AS1) in BC have rarely been
characterized. Thus, we explored whether CCDC183-AS1 is involved in the malignancy of BC and elucidated the
possible underlying mechanisms. Our data confirmed elevated CCDC183-AS1 expression in BC, which was associated
with poor clinical outcomes. Functionally, knocking down CCDC183-AS1 hampered cell proliferation, colony formation,
migration, and invasion in BC. Additionally, the absence of CCDC183-AS1 restrained tumor growth in vivo.
Mechanistically, CCDC183-AS1 executed as a competitive endogenous RNA in… More >
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