FENGXIANG TANG, YANSHI LI, MIN PAN, ZHIHAI WANG, TAO LU, CHUAN LIU, XIN ZHOU, GUOHUA HU^*

Oncology Research, Vol.31, No.5, pp. 787-803, 2023, DOI:10.32604/or.2023.030081 - 21 July 2023

Abstract Background: Lymphatic metastasis (LM) emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma (HSPSCC), chiefly contributing to treatment inefficacy. This study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in HPSCC. Methods: In a preceding investigation, HSP90AA1, a differential gene, was discovered through transcriptome sequencing of HPSCC tissues, considering both the presence and absence of LM. Validation of HSP90AA1 expression was accomplished via qRT-PCR, western-blotting(WB), and immunohistochemistry(IHC), while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA), log-rank test(LR), and Cox’s regression analysis(CRA). Bioinformatics techniques… More > Graphic Abstract

Muhannad Alsyouf¹, Jonathan Maldonado, Laura Denham², Bonnie Rohweller², Jason Groegler¹, Phillip Stokes¹, Mohammad Hajiha¹, Akin Amasyali¹, Herbert Ruckle¹, Brian Hu¹

Canadian Journal of Urology, Vol.29, No.5, pp. 11312-11317, 2022

Abstract Introduction: Perivesical lymph nodes were added to the 8th edition of American Joint Committee on Cancer (AJCC) staging for bladder cancer. Currently, these nodes are inconsistently evaluated at the time of radical cystectomy. The objective of this study was to provide a detailed anatomic evaluation of perivesical lymph nodes.
Materials and methods: A radical cystectomy was performed on six un-embalmed cadavers with wide resection of perivesical tissue and meticulous care to separate the pelvic sidewall lymph nodes (e.g. obturator, external iliac) from the bladder and perivesical en-bloc specimen. Perivesical tissue dissection in 2 mm slices was performed… More >

K. Clint Cary, Chandru P. Sundaram

Canadian Journal of Urology, Vol.15, No.6, pp. 4431-4432, 2008

Abstract Primitive neuroectodermal tumor of renal origin, PNET, is extraordinarily rare and often lethal. Here we present a case of renal PNET managed successfully by radical nephrectomy, caval thrombectomy, and retroperitoneal lymph node dissection. More >