Hua Zhang*, Xiuquan He†, Wenfei Yu†, Bingqing Yue†, Ziting Yu†, Ying Qin*
Oncology Research, Vol.27, No.8, pp. 859-869, 2019, DOI:10.3727/096504017X15049209129277
Abstract As the noncatalytic subunit of mammalian DNA polymerase, mitotic arrest-deficient protein 2B (MAD2B) has
been reported to play a role in cell cycle regulation, DNA damage tolerance, gene expression, and carcinogenesis. Although its expression is known to be associated with poor prognosis in several types of human cancers,
the significance of MAD2B expression in lung malignancies is still unclear. Our study showed that MAD2B
expression significantly increased in lung cancer, especially in the metastatic tissues. We also found that knockdown of MAD2B inhibited the migration, invasion, and epithelial–mesenchymal transition of lung cancer cells
in vitro and the metastasis in vivo,… More >
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