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  • Open Access

    ARTICLE

    Exploring the attenuation mechanisms of Dalbergia odorifera leaves extract on cerebral ischemia-reperfusion based on weighted gene co-expression network analysis

    JINFANG HU1,#, JIANGEN AO2,#, LONGSHENG FU1,#, YAOQI WU1, FENG SHAO3, TIANTIAN XU1, MINGJIN JIANG4, SHAOFENG XIONG1, YANNI LV1,*

    BIOCELL, Vol.47, No.7, pp. 1611-1622, 2023, DOI:10.32604/biocell.2023.028684

    Abstract Background: The attenuation function of Dalbergia odorifera leaves on cerebral ischemia-reperfusion (I/R) is little known. The candidate targets for the Chinese herb were extracted from brain tissues through the high-affinity chromatography. The molecular mechanism of D. odorifera leaves on cerebral I/R was investigated. Methods: Serial affinity chromatography based on D. odorifera leaves extract (DLE) affinity matrices were applied to find specific binding proteins in the brain tissues implemented on C57BL/6 mice by intraluminal middle cerebral artery occlusion for 1 h and reperfusion for 24 h. Specific binding proteins were subjected to mass-spectrometry to search for the differentially expressed proteins between… More >

  • Open Access

    ARTICLE

    Modeling for application data with 3D spatiale feature in MADS

    Chamseddine Zaki1 , Mohamed Ayet1,2, Allah Bilel Soussi2

    Revue Internationale de Géomatique, Vol.29, No.3, pp. 255-262, 2019, DOI:10.3166/rig.2019.00086

    Abstract A conceptual spatiotemporal data model must be able to offer users a semantic richness of expression to meet their diverse needs concerning the modeling of spatio-temporal data. The conceptual spatiotemporal data model must be able to represent the objects, relationships and events that can occur in a field of study, track data history, support the multirepresentation of these data, and represent temporal and spatial data with two and three dimensions features. The model must also allow the assignment of different types of constraints to relations and provide a complete orthogonality between dimensions and concepts. The MADS model meets several requirements… More >

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