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  • Open Access

    ARTICLE

    Anemarsaponin B mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation

    YI HU1,#, ZHONGYANG REN2,#, ZHENGZHONG ZHAO1, YONGJIA HUANG3, WANTING HUANG3, JIE LIU3,*, LING DING3,*

    BIOCELL, Vol.48, No.5, pp. 745-758, 2024, DOI:10.32604/biocell.2024.049140

    Abstract Background: Acute pancreatitis (AP), known for its rapid onset and significant incidence and mortality rates, presents a clinical challenge due to the limited availability of effective treatments and preventive measures. Anemarsaponin B (ASB) has emerged as a potential therapeutic agent, demonstrating capabilities in reducing immune inflammation, positioning it as a promising candidate for AP treatment. Methods: We investigated the effects of ASB on AP in mice, induced by caerulein and lipopolysaccharide (LPS). Peripheral blood samples were collected 24 h post-induction with caerulein to assess of key biomarkers including lipase, amylase, TNF-α, IL-1β, IL-6, SOD, and GSH-Px. A range of techniques… More >

  • Open Access

    ARTICLE

    MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression

    CHENG-GONG LUO1,2,#, JIAO ZHANG1,#, YUN-ZHAO AN1, XUAN LIU1, SHUAI-JIE LI1, WEI ZHANG1, KAI LI1, XU ZHAO1, DONG-BO YUAN1, LING-YUE AN1, WEI CHEN2, YE TIAN1,*, BIN XU1,*

    BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878

    Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted further investigations into the… More >

  • Open Access

    ARTICLE

    Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor

    ANDI ZHAO1,2,#, YUE WANG3,#, ZIJIN WANG1,2, QING SHAO1,2, QI GONG1,2, HUI ZHU1,2, SHIYA SHEN1,2, HU LIU1,2,*, XUEJUAN CHEN1,2,*

    Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972

    Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth… More > Graphic Abstract

    <i>Circ_0053943</i> complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of <i>Epidermal growth factor receptor</i>

  • Open Access

    REVIEW

    Do tensile and shear forces exerted on cells influence mechanotransduction through stored energy considerations?

    FREDERICK H. SILVER1,2,*, TANMAY DESHMUKH2

    BIOCELL, Vol.48, No.4, pp. 525-540, 2024, DOI:10.32604/biocell.2024.047965

    Abstract All tissues in the body are subjected externally to gravity and internally by collagen fibril and cellular retractive forces that create stress and energy equilibrium required for homeostasis. Mechanotransduction involves mechanical work (force through a distance) and energy storage as kinetic and potential energy. This leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue components. It involves the application of energy directly to cells through integrin-mediated processes, cell-cell connections, stretching of the cell cytoplasm, and activation of the cell nucleus via yes-associated protein (YAP) and transcriptional coactivator with PDZ-motif (TAZ). These processes involve numerous… More >

  • Open Access

    ARTICLE

    Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

    ZHI ZHANG1,#, XIAOSONG LI1,2,#, YING ZHANG1,2,#, HAO ZHU1,2, ZHENGUO QIAO3, YANG LU4, XIUWEI MI4, HUIHUA CAO5, GENHAI SHEN1,*, SONGBING HE4,*

    Oncology Research, Vol.32, No.2, pp. 353-360, 2024, DOI:10.32604/or.2023.042986

    Abstract Colorectal cancer (CRC) stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally. Absent in melanoma 2 (AIM2), a constituent of the interferon-inducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family, contributes to both cancer progression and inflammasome activation. Despite this understanding, the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive. Consequently, this study endeavors to assess AIM2’s expression levels, explore its potential antitumor effects, elucidate associated cancer-related processes, and decipher the underlying signaling pathways in CRC. Our findings showed a reduced… More > Graphic Abstract

    Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

  • Open Access

    Ring finger protein 157 is a prognostic biomarker and is associated with immune infiltrates in human breast cancer

    XIN ZHU1,2,#, BIN XIAO3,#,*, WENWU ZHANG3,4, XIAOYU SONG3, WEI GONG5, LINHAI LI3,*, XINPING CHEN1,2,*

    BIOCELL, Vol.47, No.10, pp. 2265-2281, 2023, DOI:10.32604/biocell.2023.029195

    Abstract Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitin ligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune cell infiltration among breast cancer patients remains to be further explored. Methods: In this study, publicly available datasets were used for evaluating RNF157 expression in different tumors compared with normal samples. Several independent datasets were screened for investigating the relationship between RNF157 and breast cancer survival, different mutation profiles, and tumor immune cell infiltration. We conducted a pathway enrichment analysis to identify signaling pathways associated with… More >

  • Open Access

    ARTICLE

    The therapeutic mechanism of dexamethasone in lung injury induced by hydrogen sulfide

    CHUNYANG XU1,#, CAIYUN YANG1,#, JINSONG ZHANG2, XIAOHUA PAN3, JUN WANG4, LEI JIANG2, HONGWEI YE1,*, BO CHEN1,*

    BIOCELL, Vol.47, No.9, pp. 2027-2035, 2023, DOI:10.32604/biocell.2023.029277

    Abstract Background: The lung is one of the primary target organs of hydrogen sulfide (H2S), as exposure to H2S can cause acute lung injury (ALI) and pulmonary edema. Dexamethasone (Dex) exerts a protective effect on ALI caused by exposure to toxic gases and is commonly used in the clinic; however, the underlying mechanisms remain elusive, and the dose is unclear. Methods: In vivo experiments: divided C57BL6 mice into 6 groups at random, 12 in each group. The mice were exposed to H2S for 3 h and 5 or 50 mg/kg Dex pretreated before exposure, sacrificed 12 h later. The morphological changes… More >

  • Open Access

    ARTICLE

    Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive UAAs activates the MAPK/ERK signaling pathway

    SHU ZHAO1,*, SHIXIN YE2

    BIOCELL, Vol.47, No.6, pp. 1377-1388, 2023, DOI:10.32604/biocell.2023.023874

    Abstract Background: This paper aims to establish a light-controlled phosphorylation detection method at the Y785 site of tropomyosin receptor kinase A (TrkA) receptor in mammalian cells by using genetic code expansion technology and detecting the effects of optical activation of this site on the downstream MAPK/ERK pathway. The study is based on the current situation that the regulatory mechanism of TrkA phosphorylation has not been fully elucidated. Methods: Two photosensitive unnatural amino acids, p-azido-L-phenylalanine (AzF) and photo-caged tyrosine (ONB) were introduced into the TrkA-Y785 site by genetic code expansion technology and site-directed mutagenesis. Western blotting and laser confocal imaging were conducted… More >

  • Open Access

    ARTICLE

    Transcriptome Analysis of Auxin Drives Cone Size Regulation in Fokienia hodginsii

    Shunde Su1,2,#, Huan Chang3,#, Xiangyang Kang1,*, Renhua Zheng2,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1713-1723, 2023, DOI:10.32604/phyton.2023.027586

    Abstract As the reproductive organ of the endangered species Fokienia hodginsii, the size of the cones is a constraint on the reproductive renewal of the population. In this study, the molecular basis of the influence of cone size on F. hodginsii was elucidated by comparing the phenotype, biochemistry, and transcriptome of two cultivars of F. hodginsii (‘FJ431’ and ‘FJ415’). The two cultivars differed significantly in cone size, with FJ431 having a significantly larger cone size and weight than FJ415, 1.32 and 1.90 times that of FJ415, respectively. RNA-Seq analysis of both cultivars retrieved 75,940 genes whose approximate functions were classified as… More >

  • Open Access

    ARTICLE

    Network pharmacology and molecular docking identify mechanisms of medicinal plant-derived 1,2,3,4,6-penta-O-galloyl-beta-D-glucose treating gastric cancer

    MAN REN1,2,3,#, YUAN YANG1,2,#, DAN LI4, NANNAN ZHAO5, YUPING WANG2,6,*, YONGNING ZHOU2,6,*

    BIOCELL, Vol.47, No.5, pp. 977-989, 2023, DOI:10.32604/biocell.2023.028402

    Abstract Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, the targets of PGG were searched in the Herbal Ingredients’ Targets (HIT), Similarity Ensemble Approach (SEA), and Super-PRED databases. The potential targets related to gastric cancer were predicted from the Human Gene Database (GeneCards) and DisGeNET databases. The intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen hub targets. Functional and… More >

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