Faizah A. AlMalki1, Aziza M. Hassan2,*, Zeinab M. Klaab1, Soliman Abdulla3, Antonio Pizzi4
Journal of Renewable Materials, Vol.9, No.12, pp. 2077-2092, 2021, DOI:10.32604/jrm.2021.016173
Abstract Recently, natural substances in the form of nanoparticles are increasingly being used in different field, particularly in medicines to enhance their beneficial effects in treatment and prevention. Cancer cells of the breast (MCF-7) have been chosen to be examined and treated in vitro with conventional drug Tamoxifen (Tam) and tannin nanoparticles extract (NP99) individually or in combination. MTT reagent has been applied to assess the cell viability and propagation percentage, DNA fragmentation and mRNA relative expression of apoptotic genes to study the cell death pathway. The results showed that Tam and tannin NP99 triggered cytotoxic activity towards the MCF-7 cell.… More >