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  • Open Access

    ARTICLE

    Stigma-Specific Comparative Proteomic Analysis Reveals the Distyly Response to Self-Incompatibility in Plumbago auriculata Lam

    Di Hu1, Shouli Yi1,*, Di Lin2, Suping Gao3, Ting Lei3, Wenji Li4, Tingdan Xu1, Songlin Jiang1

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 681-697, 2024, DOI:10.32604/phyton.2024.049166

    Abstract In plants, heteromorphic self-incompatibility (HetSI) is a strategy for avoiding self-pollination and promoting outcrossing, and during this process, numerous protein-protein interaction events occur between the pistil and pollen. Previous studies in Primula and Fagopyrum that focused on HetSI systems have provided interesting insights; however, the molecular mechanism underlying HetSI remains largely unknown. In this study, we profiled the proteome of Plumbago auriculata stigmas before and after self-incompatible (SI) and self-compatible (SC) pollination. Comparative analyses were conducted by 4D-DIA (Four-dimensional data independent acquisition), a promising technology that increases the sensitivity and reduces the spectral complexity of proteomic analysis by adding a… More >

  • Open Access

    ARTICLE

    FLOWERING LOCUS T (FT) in Photosensitive Type Chrysanthemum Accelerates Flowering in Arabidopsis

    Fenglan Wang#, Zhenyuan Cai#, Zhimei Li, Shilong Zhang, Honghui Luo, Qing Wu, Hanhan Xia, Yanhong Guo*

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 819-830, 2024, DOI:10.32604/phyton.2024.049150

    Abstract FLOWERING LOCUS T (FT) is an important factor for integrating flowering signals through the photoperiod pathway, which significantly promotes flowering. Most chrysanthemum varieties are short-day plants, sensitive to the photoperiod, which limits their ornamental and annual production supply. In this study, we aim to analyze the nutrients and flowering-related genes of chrysanthemums with different photoperiod types and to clone and verify the function of the flowering-related gene CmFT. We found that the formation of floral buds requires the accumulation of starch while consuming soluble sugars and the expression patterns of flowering-related genes GIGANTEA (GI), CONSTANS (CO), and FT in C.morifoliumMore >

  • Open Access

    ARTICLE

    Profiles of the Headspace Volatile Organic and Essential Oil Compounds from the Tunisian Cardaria draba (L.) Desv. and Its Leaf and Stem Epidermal Micromorphology

    Wissal Saadellaoui1, Samiha Kahlaoui1, Kheiria Hcini1, Abir Haddada1, Noomene Sleimi2,*, Roberta Ascrizzi3, Guido Flamini3, Fethia Harzallah-Skhiri4, Sondes Stambouli-Essassi1

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 725-744, 2024, DOI:10.32604/phyton.2024.048110

    Abstract In this work, we investigated aroma volatiles emanated by dry roots, stems, leaves, flowers, and fruits of Cardaria draba (L.) Desv. growing wild in Tunisia and its aerial part essential oils (EOs) composition. A total of 37 volatile organic compounds (96.7%–98.9%) were identified; 4 esters, 4 alcohols, 7 hydrocarbons, 12 aldehydes, 5 ketones, 1 lactone, 1 organosulfur compound, 2 organonitrogen compounds, and 1 acid. The hydrocarbons form the main group, representing 49.5%–84.6% of the total detected volatiles. The main constituent was 2,2,4,6,6-pentamethylheptane (44.5%–76.2%) reaching the highest relative percentages. Forty-two compounds were determined in the two fractions of EOs, representing 98.8%… More >

  • Open Access

    ARTICLE

    Deep-Ensemble Learning Method for Solar Resource Assessment of Complex Terrain Landscapes

    Lifeng Li1, Zaimin Yang1, Xiongping Yang1, Jiaming Li2, Qianyufan Zhou3,*, Ping Yang3

    Energy Engineering, Vol.121, No.5, pp. 1329-1346, 2024, DOI:10.32604/ee.2023.046447

    Abstract As the global demand for renewable energy grows, solar energy is gaining attention as a clean, sustainable energy source. Accurate assessment of solar energy resources is crucial for the siting and design of photovoltaic power plants. This study proposes an integrated deep learning-based photovoltaic resource assessment method. Ensemble learning and deep learning methods are fused for photovoltaic resource assessment for the first time. The proposed method combines the random forest, gated recurrent unit, and long short-term memory to effectively improve the accuracy and reliability of photovoltaic resource assessment. The proposed method has strong adaptability and high accuracy even in the… More >

  • Open Access

    ARTICLE

    Intelligent Machine Learning Based Brain Tumor Segmentation through Multi-Layer Hybrid U-Net with CNN Feature Integration

    Sharaf J. Malebary*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1301-1317, 2024, DOI:10.32604/cmc.2024.047917

    Abstract Brain tumors are a pressing public health concern, characterized by their high mortality and morbidity rates. Nevertheless, the manual segmentation of brain tumors remains a laborious and error-prone task, necessitating the development of more precise and efficient methodologies. To address this formidable challenge, we propose an advanced approach for segmenting brain tumor Magnetic Resonance Imaging (MRI) images that harnesses the formidable capabilities of deep learning and convolutional neural networks (CNNs). While CNN-based methods have displayed promise in the realm of brain tumor segmentation, the intricate nature of these tumors, marked by irregular shapes, varying sizes, uneven distribution, and limited available… More >

  • Open Access

    REVIEW

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

    KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*

    Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

    Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

  • Open Access

    ARTICLE

    Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of GNAL in glioma

    ZHEN LIU1,#, LIANGWANG YANG2,#, ZHENGXING XIE1, HUI YU3, TIANYI GU3, DAOMING SHI4, NING CAI1,*, SHENGHUA ZHUO2,*

    Oncology Research, Vol.32, No.5, pp. 965-981, 2024, DOI:10.32604/or.2024.045769

    Abstract Clinical data indicates that glioma patients have poor treatment outcomes and clinical prognosis. The role of olfactory signaling pathway-related genes (OSPRGs) in glioma has not been fully elucidated. In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion… More >

  • Open Access

    ARTICLE

    Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

    JINGJING CHEN1, DAN WANG2, ZEQUN WANG2, MENGYUAN HAN4, HOUQING YIN2, WENTING ZHOU4, RIBAI YAN5, YAN PAN2,3,*

    Oncology Research, Vol.32, No.5, pp. 911-923, 2024, DOI:10.32604/or.2023.042384

    Abstract Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901… More > Graphic Abstract

    Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

  • Open Access

    ARTICLE

    Study of the Ballistic Impact Behavior of Protective Multi-Layer Composite Armor

    Dongsheng Jia, Yingjie Xu*, Liangdi Wang, Jihong Zhu, Weihong Zhang

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 171-199, 2024, DOI:10.32604/cmes.2024.046703

    Abstract The abalone shell, a composite material whose cross-section is composed of inorganic and organic layers, has high strength and toughness. Inspired by the abalone shell, several multi-layer composite plates with different layer sequences and thicknesses are studied as bullet-proof material in this paper. To investigate the ballistic performance of this multi-layer structure, the complete characterization model and related material parameters of large deformation, failure and fracture of Al2O3 ceramics and Carbon Fiber Reinforced Polymer (CFRP) are studied. Then, 3D finite element models of the proposed composite plates with different layer sequences and thicknesses impacted by a 12.7 mm armor-piercing incendiary… More >

  • Open Access

    ARTICLE

    miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

    LIJUAN ZHANG1,#, QINGYIN MENG2,#, LI ZHUANG1, QUAN GONG1, XIANDA HUANG3, XUEQIN LI1, SHIJUAN LI1, GUOQIN WANG4, XICAI WANG5,*

    BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260

    Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells. Furthermore, we examined tumorigenesis and… More > Graphic Abstract

    miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

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