AFRAH ALKHURIJI1, ATEKAH ABDULLAH MOHAMMED ALRAQIBAH1, AMAAL AWAD ALHARBI1, ZENEB BABAY2, FATIMAH BASIL AL-MUKAYNIZI3, ARWA ALTHOMALI3, SONYA S. ABDEL-RAZEQ4, ARJUMAND S. WARSY5
BIOCELL, Vol.44, No.4, pp. 613-621, 2020, DOI:10.32604/biocell.2020.09652
Abstract Methylenetetrahydrofolate reductase (MTHFR) deficiency is the most common genetic cause of
hyperhomocysteinemia, which has been implicated in the etiology of recurrent spontaneous abortion (RSA). This
study was designed to investigate the association between two single nucleotide polymorphisms (SNP) (rs1801133
[C677T] and rs1801131 [A1298C]) in the MTHFR gene and RSA, in Saudis. These two SNPs were selected as these
polymorphisms have a different effect on the activity and stability of the enzyme, and significantly diverse effects have
been reported in relation to the association with RSA. Ethical approval was acquired from the IRB at King Saud
University (KKUH), Saudi Arabia, and… More >
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