Muhammad Rafiq¹, Ali Ahmadian^{2, *}, Ali Raza³, Dumitru Baleanu⁴, Muhammad Sarwar Ahsan¹, Mohammad Hasan Abdul Sathar⁵

CMC-Computers, Materials & Continua, Vol.65, No.1, pp. 33-51, 2020, DOI:10.32604/cmc.2020.010893 - 23 July 2020

Abstract Nonlinear stochastic modeling has significant role in the all discipline of sciences. The essential control measuring features of modeling are positivity, boundedness and dynamical consistency. Unfortunately, the existing stochastic methods in literature do not restore aforesaid control measuring features, particularly for the stochastic models. Therefore, these gaps should be occupied up in literature, by constructing the control measuring features numerical method. We shall present a numerical control measures for stochastic malaria model in this manuscript. The results of the stochastic model are discussed in contrast of its equivalent deterministic model. If the basic reproduction number More >

Aknur Turgumbayeva^1,2, Gulbaram Ustenova¹, Ubaidilla Datkhayev¹, Khairolla Rahimov³, Silvijus Abramavicius^4,5, Agile Tunaityte^4,*, Kairat Zhakipbekov^1,6, Kaldanay Kozhanova¹, Saken Tulemissov⁷, OzikhanUstenova⁸, Gulmira Datkayeva⁹, Edgaras Stankevicius^1,10

Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665 - 01 March 2020

Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the More >

Vijay L. KUMAR^{1 *}, B. GURUPRASAD¹, Priyanka CHAUDHARY²

BIOCELL, Vol.38, No.1, pp. 1-6, 2014, DOI:10.32604/biocell.2014.38.001

Abstract Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of artesunate in the rat paw edema model. Inflammation was induced in the hind paw of rat by sub-plantar injection of 0.1 mL of 0.5% carrageenan and the paw volume was measured up to a fixed mark just before the injection and then after 3 h. The difference in two volumes gave a measure of edema formation. At 3h the level of TNF-α, PGE2 and myeloperoxidase More >

Matthew B. B. McCall^1,*, Bart Ferwerda^2,*, Joost Hopman¹, Ivo Ploemen¹, Boubacar Maiga³, Modibo Daou³, Amagana Dolo³, Cornelus C. Hermsen¹, Ogobara K. Doumbo³, George Bedu-Addo⁴, Jos W. van der Meer², Marita Troye-Blomberg⁵, André J. A. M. van der Ven², Ralf R. Schumann⁶, Robert W. Sauerwein¹, Frank P. Mockenhaupt⁷, Mihai G. Netea²

European Cytokine Network, Vol.21, No.2, pp. 77-83, 2010, DOI:10.1684/ecn.2010.0187

Abstract Background. The full-length (L-) variant of caspase-12 is believed to predispose to sepsis. It has been replaced in the genome of most human populations by the (S-) variant, which leads to premature termination of translation. Strikingly, the L-allele is still widely prevalent in African populations, presumably due to a counterbalancing selective force specific to this continent, for which malaria is a prime candidate. Methods. We investigated associations between caspase-12 genotype and malarial parameters in three West-African populations, in studies encompassing immunological, clinical and obstetric data. Results. The caspase-12 L-allele was found at frequencies of 11-34%. Plasmodium… More >

Swapnil Sinha¹, Tabish Qidwai¹, Kanika Kanchan¹, Ganga N. Jha¹, Prerna Anand², Sudhanshu S. Pati³, Sanjib Mohanty³, Saroj K. Mishra³, Prajesh K. Tyagi⁴, Surya K. Sharma⁴, Shally Awasthi², Vimala Venkatesh², Saman Habib¹

European Cytokine Network, Vol.21, No.4, pp. 232-240, 2010, DOI:10.1684/ecn.2010.0208

Abstract The immune effector response to Plasmodium falciparum infection involves a finely-tuned inter-play between different cell types and cytokines. However, the processes by which they mediate the development of clinical immunity, in areas of different endemicity, are poorly understood. We analyzed circulating levels of pro-inflammatory (TNF, IFN-γ, IL-12, IL-16) and anti-inflammatory (IL-4, IL-10, IL-13) cytokines in control and patient groups drawn from a P. falciparum-endemic and a non-endemic region of India. The endemic region control population exhibited a lower pro- to anti-inflammatory cytokine ratio, indicating a shift towards a high basal Th2 response. Levels of IL-10 contributed most… More >

Yohsuke Imai, Hitoshi Kondo, Young Ho KANG, Takuji Ishikawa Chwee Teck Lim, Takami Yamaguchi

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 205-206, 2009, DOI:10.3970/icces.2009.009.205

Abstract Malaria is one of the most serious infectious diseases on earth. We have about five hundred million patients with two million deaths. When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent. We propose a numerical model of hemodynamics arising from malaria infection. Our model is based on a Lagrangian and free mesh method (particle) method. A spring network model is employed to compute elastic force generated by the deformation of IRBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by More >

Ludovic Mewono^1,2,*, Davy W. Matondo Maya^1,2,*, Pierre-Blaise Matsiegui^1,2, Selidji T. Agnandji^1,2, Eric Kendjo^2,3, Fortune Barondi¹, Saadou Issifou¹, Peter G. Kremsner^1,2, Elie Mavoungou^1,2

European Cytokine Network, Vol.19, No.1, pp. 30-36, 2008, DOI:10.1684/ecn.2008.0114

Abstract Interleukin-21 (IL-21) is a newly described, typical, four-helix cytokine showing significant homology with IL-2, IL-4 and IL-15. It regulates IgG1 production and co-operates with IL-4 in the production of multiple antibody classes in vivo. IgG1 and IgG3 are critically involved in the development of clinical immunity to Plasmodium falciparum malaria. However, the mechanisms driving class-switch recombination towards these specific isotypes remain to be elucidated. Seventy-three children with P. falciparum-positive, thick blood smears were recruited from the pediatric wards of the Albert Schweitzer Hospital and the General Hospital in Lambaréné. Children were grouped into two categories according to… More >

Davy W. Matondo Maya^1,2, Ludovic Mewono^1,2, Anne-Marie Nkoma¹, Saadou Issifou¹, Elie Mavoungou¹

European Cytokine Network, Vol.19, No.3, pp. 123-130, 2008, DOI:10.1684/ecn.2008.0129

Abstract We investigated associations between markers of damage of vascular endothelial cells (MDVECs) and plasma cytokine levels, hemoglobin level and temperature in individuals with acute uncomplicated malaria, as well as healthy controls, using enzyme linked immunosorbent assay (ELISA) for the presence of soluble endothelial cell adhesion molecule-1 (sE-selectin), circulating granule membrane protein-140 (sP-selectin), circulating thrombomodulin (TM), circulating von Willebrand factor (VWf), interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). Significant differences were observed between malaria patients and the healthy people in term of levels of both sE-selectin and TM. The serum levels of sP-selectin and More >

Laurianne Giovannoni

European Cytokine Network, Vol.19, No.4, pp. 196-203, 2008, DOI:10.1684/ecn.2008.0136

Abstract Malaria causes more than one million deaths annually, worldwide. Understanding the genetic defenses against this disease is an important challenge for science. We know that the long-term presence of endemic malaria has led to a prevalence of the β°39 heterozygous thalassemia mutation in the two islands of Corsica and Sardinia. The populations of both islands are isolated, which could make it easier to find other genetic traits selected by disease pressure. We chose to investigate genes implicated in the primary defenses against Plasmodium falciparum: oxidative metabolism and the immune response. We indeed selected genes coding for More >

Pierre-Blaise Matsiegui^1,2, Michel A. Missinou^1,2, Saadou Issifou¹, Magdalena Necek^1,3, Elie Mavoungou^1,2

European Cytokine Network, Vol.18, No.4, pp. 201-205, 2007, DOI:10.1684/ecn.2007.0105

Abstract We assessed the ability of ibuprofen to modulate tumor necrosis factor α (TNF-α), soluble tumor necrosis factor receptor type I (sTNFR-I), and soluble tumor necrosis factor receptor type II (sTNFR-II) responses during the treatment of fever in uncomplicated Plasmodium falciparum malaria, in a placebo-controlled, randomized, double-blind study of 50 pediatric patients in Lambaréné, Gabon. Treatment of the malaria involved the patients receiving intravenous quinine (12 mg/kg of quinine dihydrochloride every 12 h for 72 h) followed by a single dose of oral sulfadoxine/pyrimethamine (25 mg and 1.25 mg/kg). Fever was treated by mechanical treatment plus either… More >